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0 7 0 93 0 2 Ц 0 9 ю 0 1 0 3 0 7 0 0 0 7? 0 3 0 93 0 8 0 4 0 3 0 1 0 9 ю 0 0 0 0 0 0 0 3een et al. 2003) a tak karcinom 0 6aludku, 0 0

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0 5 0 4 0 97 0 5 0 4 0 2 0 9-0 7 0 3 0 1 0 3 0 7 0 4 0 8 0 3 0 0 Ц ю 0 8 0 1 0 3 0 37 0 6 Л 0 0 0 7 ю 0 9? 0 2 0 7 0 3 0 5 ю 0 5 0 4 0 1 0 7 0 4 0 5 0 3 0 5 0 3 0 93 0 6 0 3 0 7 0 7 0 3 Ц 0 8 ю 0 57 0 2 0 1 0 3 0 4 0 5 Л 0 1 ю 0 9 0 3 0 9? 0 5 0 4 0 2 0 9-0 7 0 4 0 2 0 3 Ц 0 3 ю 0 5? 0 53 0 9 0 4 0 7? 0 8 0 7 0 4 0 5 0 7 0 7 0 3 Ц 6 9 0 3 0 93 0 9 0 4 0 8 ю 0 3 0 3 0 4 0 8 0 1 0 3 0 9 0 4 0 7 0 0 0 9 0 0 0 2 0 1 0 3 0 4 0 5 Л 0 0 Ц 3 Ц 0 4 0 5 0 9 0 3 0 2 0 4 0 1 0 5 0 93 0 6 ю Ц 0 2 0 3 0 4 0 7? 0 3 ю 0 5 0 3 Ц ю 0 7 0 1 0 5 0 93 0 27 0 3 ю 0 7 ю 0 2 0 3 0 9 0 3 0 6 ю 0 5 Л 0 2 ю 0 87 0 0 ю 0 8 0 7 0 9 0 1 0 87 0 0 ю Ц ю 0 5 0 3 0 7 en na celiakii je u 0 6ite n zv 0 6it HLA genotypizaci, proto 0 6e 99 % pacient 0 2 0 1 0 3 0 7 0 4 0 8 3 0 9 0 2 ю 0 0 0 9 ю 0 2 0 1 0 3 0 7 0 4 0 7 0 3 0 2 Ц ю 0 9 0 3 0 5 0 97 0 7 0 3 0 2 0 1 0 3 0 7 0 4 0 8 3 0 2 ю 0 0 0 5 0 2 0 3 0 93 0 13 0 1 0 0 0 9 0 8 0 8 0 4 0 7 0 3 0 7 0 0 0 1 0 4 0 3 0 3 0 7 0 7 0 3 0 1 0 4 0 7 0 6 0 4 0 4 б 0 4 0 3 Ц 3 0 1 ю 0 0 0 9 ю 0 2 0 1 0 4 0 7 0 3 0 2 Ц ю 0 9 0 3 0 5 0 97 0 7 0 1 0 1 0 0 0 1 ю 0 4 0 7 0 3 0 7 0 2 Ц ю 0 7 0 0 0 2 0 9 0 3 0 2 0 4 0 1 0 5 0 93 0 6 ю Ц 0 2 3 0 0? 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Maiuri et al. ve sv studii ukazuje, 0 6e n 0 8 0 1 0 3 0 37 Ц 0 3 Ц 0 1 0 5 Л 0 7 0 3 Ц 0 8 0 0 0 5 Л 0 5 ю 0 7? 0 5 0 4 0 93 Ц 0 3 ю 0 7 0 3 0 9 ю 0 0 0 3 0 3 0 4 0 8 0 1 0 0 0 7 0 4 0 13 0 0 0 1 ю 0 9 0 97 3 0 53 0 4 0 5 0 4 Ц 0 1 0 5 0 93 0 0 0 0 0 9 0 1 0 0 0 0 0 7 0 4 0 0 0 3 0 3 0 1 0 4 0 7 0 6 0 4 0 4 б 0 6 0 5 0 0 0 2 0 2 0 7 Л 0 0 0 6 ю 0 1 Л 0 1 Л 0 0 а 0 2 0 8 0 2 0 7 0 9 0 1 0 3 0 4 0 3 Ц 0 1 0 3 0 7? 0 7 0 93 0 7 Л 0 0 0 6 ю 0 1 Л 0 1 Л б 0 6 Л 0 7 Л 0 9 0 4 0 3 ю 0 7 0 53 0 7 ю 0 5 0 6 0 5 0 2 0 2 0 6 0 0 0 9 k pova 0 6ov ny v patogenezi celiakie 0 7 0 4 0 9 0 3 Ц ю 0 5 0 2 0 1 0 4 0 1 0 97 0 9 0 3 0 6 ю Ц 0 9 0 3 0 9 0 0 0 3 0 9 6 93 0 0 0 7 0 4 0 5 0 3 0 0 0 0 ю 0 1 0 97 0 3 0 9 6 9 0 1 n, 0 6e by se IELs mohly podrobit malign 0 1 0 3 0 4 0 9 0 2 0 6 ю 0 3 0 0 0 4 0 1 0 4 0 3 Ц 0 3 0 0 ю 0 5 0 4 0 1 0 5 Л 0 2 ю 0 8 ю 0 0 & 0 3 ю 0 5 0 3 0 1 Л 0 1 ю 0 1 ю 0 1 0 8# 0 1 0 0 0 2 0 3 0 4 0 9 0 0 0 73 0 4 0 9 0 1 0 3 0 3 0 6 0 3 0 3 ю 0 9 0 0 0 5 6 9 0 4 0 8 0 9 0 4 0 7 0 9 0 4 0 0 0 9 0 3 0 0 0 6e IELs byly aktivov ny (Green and Jabri 2003). 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0 1 0 0 0 4 0 0 0 4 0 8 0 3 ю 0 6? 0 73 0 1 0 0 0 5 0 1 0 3 0 77 0 0 0 7 0 5 0 3 0 4 0 57 0 0 0 7 0 3 0 0 0 4 0 1 0 7 0 0 0 2 0 17 0 0 0 2 0 1 0 3 0 5 0 0 0 6 0 4 0 3 ю 0 6 0 4 0 4 0 5 0 2 0 1 0 1 0 1 0 3 0 3 0 1 0 4 0 7 0 6 0 4 0 4 0 2 0 2 0 0 0 3 0 2 0 3 0 1 0 4 0 7 0 6 0 4 0 4 б 0 0 0 5# 0 7 0 9 0 4 0 0 0 9 0 2 0 3 0 5 6 9 0 4 0 8 0 7 0 5 Л 6 9 0 0 0 93 0 5 0 5 ю 0 7 0 93 0 0 0 2 0 4 0 2 0 1 0 3 ю 0 9 0 1 0 3 0 2 0 1 0 9? 0 7 0 93 0 0 0 1 0 3 0 4 0 8 0 1 0 0 Ц 0 4 0 8 0 1 0 5 0 93 0 6? 0 7 0 2 0 4 0 2 0 1 0 3 ю 0 9 0 1 0 3 0 2 0 1 0 9? 0 7 0 93 0 1 0 0 ю 0 9 0 3 0 0 ю 0 1 0 9 0 93 0 0 0 9 0 4 0 0 0 2 0 0 0 4 0 9 0 9 0 3 0 1 0 4 0 7 0 6 0 4 0 4 0 6 б 0 3 0 0 0 9 Л Ц 0 3 ю 0 9 0 3 0 5 0 0 0 2 0 8 0 2 0 6 0 4 0 2 0 8 0 2 0 5 0 5 0 0 ю 0 5 0 3 0 9? 0 7 0 93 0 2 0 7 0 7 0 9 0 1 Ц 0 4 0 1 0 3 0 9 0 1 0 2 0 1 0 3 0 7 0 4 0 8 3 Ц ю 0 5 Ц ю 0 3 0 0 0 93 0 0 Л Ц ю 0 17 0 7 0 0 & 0 4 0 2 0 1 0 5 0 3 ю 0 7 0 3 0 97 0 0 0 0 0 9 0 1 0 93 ю 0 5 Ц ю 0 5 0 5 0 5 Ц 0 4 0 1 ю 0 2 0 3 0 9 0 3 0 7 0 1 0 3 0 7 0 4 0 8 0 3 0 0 0 3 ю 0 7 0 3 0 9? 0 4 0 8 0 1 0 5 0 4 0 1 0 3 0 3 Ц 0 1 0 3 0 7 ю 0 5# 0 1 0 0 0 6 0 0 0 9 0 8 0 7 0 3 Ц 0 8 0 3 0 0 0 9 0 3 0 7? 0 8 0 7 0 4 0 5 0 93 0 0 Ц 0 3 0 5 Ц ю 0 8 0 7 0 4 0 5 0 3 0 0 Ц 0 3 ю Ц 0 4 0 1 ю 0 2 0 3 0 9 0 3 0 7 celiakie, proto 0 6e indukuje expresi neklasick 0 5ch mol 0 3 0 8 0 0 0 7 0 7 0 9 0 6 а 0 1 3 0 5 Л 0 4 а 0 8 0 2 0 5 0 0 0 8 0 1 0 3 0 37 0 9 0 2 ю 0 0 Ц ю 0 1 0 3 0 6 0 97 Ц 0 3 ю 0 5 Л 0 7 0 6 0 3 ю 0 9 ю 0 5? 0 93 а 0 2 0 8 0 2 0 8 0 7 0 4 0 63 0 9 0 3 0 93 0 3 Ц 0 1 0 3 0 7 ю 0 5# 0 1 0 0 0 6 0 0 0 9 0 8 0 4 0 1 0 07 0 9 0 0 ю 0 7 0 3 0 8 0 0 0 7? 0 3 0 93 0 7? 0 8 0 7 0 4 0 5 0 5 ю 0 8 0 7? 0 5 0 4 0 93 0 13 0 1 Л 0 1 ю & 0 9 0 8 Л 0 7 0 3 Ц 0 8 0 0 0 9 0 4 0 3 Ц 0 1 0 3 0 7? 0 7 0 93 0 6 0 0 0 8 Л 0 0 0 0 0 23 0 6# 0 1 ю 0 6 0 9 0 4 0 2 0 9 0 9 0 2 ю 0 7 0 3 а 0 4 0 3 Ц 0 1 0 3 0 7 0 4 0 8 0 7 0 2 0 1? 0 5? ю 0 1 0 3 0 5 0 3 0 9 ю 0 0 ю 0 1? 0 7 0 8 ю 0 0 а 0 3 0 4 je pova 0 6ov n za cytokin vrozen imunity, kter 0 5 m 0 6e vyvolat aktivaci APC, IL-15 0 4 Ц 0 3 ю 0 5 0 0 0 8 0 1 а 0 3 0 4 0 3 0 3 0 8 0 5 0 4 Ц 0 5 0 3 Ц 0 3 0 3 0 2 0 3 а 0 3 0 4 0 5 0 1 0 3 0 7 0 4 0 8? 0 7 0 93 0 2 0 7 0 7 0 9 0 1 0 9 0 3 0 93 0 2 Ц ю 0 9 ю 0 5? 0 9 0 4 0 2 0 1 0 5 ю 0 3 0 6 ю 0 0 а 0 8 0 2 0 6 (Nilsen et al. 1998), co 0 6 nazna uje, 0 6e produkci IFN- 0 7 0 3 0 9 0 0 3 0 53 0 5 0 4 0 7 6 93 0 1 Л 0 1 ю 0 8 0 9 Л 0 4 0 3 0 9 Ц 0 3 0 4 0 5 0 5 Ц ю 0 5 ю 0 6 0 9 0 9 6 93 0 0 0 8 0 4 0 9 0 5 0 5? 0 1 Л 0 9 0 2 ю 0 0 а 0 8 0 2 0 0 0 4 а 0 3 0 4 0 3 ю 0 1 0 3 0 9 0 1? 0 7 0 93 0 3 ю 0 7 0 3 а 0 3 0 4 0 9 0 3 Ц ю 0 5 Ц ю 0 3 ю 0 5? 0 9 0 4 0 2 0 8 0 0 0 1 0 3 nost, 0 6e celiakie byla vyvol na l 0 6 ю 0 0 а 0 3 0 4 0 0 Ц 0 4 0 1 0 3 0 9 0 1 0 2 0 0 0 3 Ц 0 4 0 1 0 1 0 5 ю 0 0 0 6 0 0 0 6 0 4 0 0 0 0 0 4 0 3 ю 0 1 0 4 0 3 0 1 0 4 0 7 0 6 0 4 0 4 0 4 0 2 0 5 0 0 0 3 0 4 0 9 0 1 0 3 0 7 0 4 0 9 0 2 ю 0 9 0 3 0 1 0 4 0 7 0 6 0 4 0 4 0 2 0 7 ю 0 9 0 1 0 3 0 7 0 3 ю 0 9 0 3 0 3 0 1 0 4 0 7. 2001) a 0 6e sliznice u pacient 0 2 0 4 0 8 0 1 0 5 0 93 celiaki exprimuje v 0 5znamn mno 0 6stv IFN- 0 4 0 1 0 07 0 9 0 0 0 9 0 5 0 0 0 8 0 1 0 3 а 0 3 0 4 0 7 0 3 Ц 0 8 0 3 0 0 0 0 0 8 0 3 0 6 0 2 0 9 0 3 0 6 ю 0 3 Ц 0 1 0 3 0 7 ю 0 5# 0 1 0 0 0 6 0 0 0 9 0 8 0 9 0 3 0 6 Л 0 7 0 4 Ц 0 3 ю 0 8? 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