2 - P - 2 2 2 2 2 2 l 2 * / ( ), -, ) %( % # # % ( ) *,- #*,- / ž # ž #ž *,- # 2 = > 7 9 =@ > A 5 ; => * ( 2 4 2 / 5 / 6 2 2 4 5 6 # 7 # ; < 7 6 4 9 / 9 : 6 B 9 D F 5 9 GF / D 9 G % = 9 2 7 % %( ) ) 2,- 7 2 ) ) 2 # 2 2 < = 9 >, 2 A - * ; 2 2 9 : ** @ 2
2 2 2 B 2 7 D 5 2 F 2 2 G ) A 7IJ9 B *K L- - ;M / /, - 7 9 D #@,@/@- - ; #, - 2 eribozomální syntéza microcystin a nodularin 2 5 7 @ 2 2 2 J K B @F 2 5 7 I 2 9 K # % Detoxifikace G, GT, GTR, I = % J K D P J5, ; < 5 / ) ) G7 ; L I L M G7 2
J9 ) ) > 2 D 9 B 5 2 2 2 Q 9 B 2 9 B 2 R P J4 ) = )> 2 R 9 B 2 J # 2 2 ) 5 # 2 L 2 T 9 B #% 2 2 2 = @ @- - :7 :>- - - - @ U,- - - - @ 2 #% 2 F 2 %%- /)*, 7 # #%9: 2- ))*, -%- /)*, ())*, 4 # 5))* 6 %#%- ))*, )*, %# 2 VK / W 2 % % ( ) 2 5 5 B X VY 5 # B X ;,- 2 2 Z %# 2 B X V 2 T B X V F #,M /* # 2 T LP P P
2 : 2 2 2 () 2 7 * % % % % % ( ),, %# # 2 2 T ()* 2 2 7 2 P - 5 # T[ 2 2 # B Q 2 2 (( * 2 2 @- # % 2 W 2 - # \ 5 # 2 Q F :M /* 2 ] %% # 2 L * 2 < JI % ( 5 2 * * * * < 2 2 2 P I P D P \,- 2 2 ZZZ 2 2 I 4## Biologicky aktivní metabolity sinic 2 Microviridiny ca 5 strukturních variant yanopeptoliny (cyanopeptoliny, micropeptiny, aeruginopeptiny, microcystilidy, planktopeptiny, oscillapeptiny, anabaenopeptilidy, oscillapeptilidy, nostopeptiny) cca 6 strukturních variant 2 2 Anabaenopeptiny (anabaenopeptiny, nodulapeptiny, oscillamidy, ferintoic acid) cca 2 strukturních variant 2 Aeruginosiny (aeruginosiny, suomilid, spumiginy, microciny) cca strukturních variant Microgininy (microgininy, radiosuminy, camabiny, oscillagininy) cca strukturních variant 4
Biologicky aktivní metabolity sinic Biologicky aktivní metabolity sinic Aplysiatoxin Malevamidy cca strukturní varianty Dendroamidy (microcyclamide, banyascyclamide, tenuecyclamide, westiellamide, nostocyclamide) cca strukturních variant cca 5 dalších hepta, octa a nonapeptid Lyngbyatoxin 2 l 2 2-epi-hapalindol isonitril Mirabizol geosmin mueggelone Microcoliny a miramibidy cca strukturních variant calothrixin A - glykolipidy 2 2 * B L / < < 2 F 9 * * B 2 F 9 2 F 9 / # G4 4 B * % # % % %% / * * / / 2 ; V ZZZ ; F 9 - F 9 * B W ^ < F 9 P P P / 2 ) JT / 2 7 ) ) IB B,:> A \\ \ ( 6 ) ) JJ# 5
/ 2 7 # ) JT B J - 4 ) 6 567 7#9 7 ) : 76 ( (; Location (source) Year Drinking water yanobacteria Toxin ealth outcomes Year Location (source) yanobacteria Toxi n ealth outcomes 9 96-965 975 979 9 977-996 972-99 9 994 UA, hio river Zimbabwe, arare UA, Pennsylvania Australia, Palm Island Australia, Armidale hina hina Brazil, Itaparica dam weden, Malmö chizotrix, Lyngbya, Phormidium ylindrospermopis, Anabaena Planktothrix Y M M M M Gastroenteritis, abdominal pain, vomiting Gastroenteritis Gastroenteritis Gastroenteritis, liver, kidney and intestine damage Liver damage olorectal cancer, deaths Primary liver cancer, deaths Gastroenteritis, diarrhoea, deaths Gastroenteritis, fevers, abdominal and muscular pain Recreational/occupational water contact 959 anada, askatchewan, Anabaena circinalis 9-9 UA, Pennsylvania and Aphanizomenon, evada Anabaena 99 UK, ngland, tafordshire 995 Australia, Anabaena, Aphanizomenon, odularia 996 UK Planktothrix 996-99 Australia (coastal sea) Lyngbya 22-2 Finland Anabaena lemmermannii M M TX eadache, nausea, muscular pain, vomiting, diarrhoea, ye and ear irritation, flu like symptoms Gastroenteritis, sore throat, blistered mouth, vomiting, abdominal pain, fever, pulmonary consolidation, diarrhoea Gastroenteritis, flu like symptoms, blistered mouth, fever, eye and ear irritation, vomiting, diarrhoea Rashes, fever ontact dermatitis, eye and ear irritation, respiratory irritation Fever, eye irritation, abdominal pain, rashes (; ( Year Location (source) yanobacteria Toxi n ealth outcomes I[ Q _ A - / Drinking water aemodialysis 974 UA, Washington 996 Brazil, aruaru 2 Brazil, Rio de Janeiro Present Present Anabaena, LP M, Y M Fever, myalgia, chills, vomiting Visual disturbance, tinitus, nausea, vomiting, liver damage, deaths Visual disturbance, tinitus, nausea, vomiting, liver damage / ] G IJ G ) =- / ] G 6
< W ` = A, A> >:a 6 )#* ( # G B IB B B > 6 )#* 4 ( BG B I 6 K P # > @ % = 2 b c A M / / =#; / # V # _ < ;#>@=#@ / P - ( J J - = 2 ( J )@ ; QJ % 4 5 @A /@- - @ # 7 4 4 / 9 : 6 G7 9 7 6 ( / 6 ( 4 : / 9 : 6 V ) ;) Q ( R@ ) @ ) # 2 )#* 2 2 2 2 2 T 2 2 - l 2 > % - P - 2 2 2 )#* 2 2Q J J # % ) % 4 J ;) Q 9 B > @- -, 2 2 9 B 5 # )#* % # )#* % 7
>- 5 ) = < I ; I, - G7 % 2 W 5 7 5 ; - - a >a >- 2 V 5 5 - - a d L 6 _ 9 B *K P P # @ # % ()*,