ACTA MEDICINAE 8/2014 Onkologie

ACTA MEDICINAE 8/2014 Onkologie Kompletní literatura 2 Predikce incidence a prevalence nádorových onemocnění a počtu léčených onkologických pacientů v ČR v letech 2015 a 2020 doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha RNDr. Tomáš Pavlík, Ph.D. RNDr. Ondřej Májek, Ph.D. Mgr. Jakub Gregor, Ph.D. IBA, LF MU, Brno RNDr. Jan Mužík, Ph.D. IBA, LF MU, Brno, ÚZIS ČR, Praha RNDr. Denisa Malúšková Mgr. Jana Koptíková, Ph.D. Mgr. Zbyněk Bortlíček IBA, LF MU, Brno prof. MUDr. Jitka Abrahámová, DrSc. Thomayerova nemocnice, Praha 2 Predikce počtu pacientů indikovaných k vyšetření PET/CT v ČR: první výsledky projektu PET/CT-CZ (Q) doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha prof. MUDr. Jiří Petera, Ph.D. doc. MUDr. Jiří Doležal, Ph.D. Fakultní nemocnice Hradec Králové prof. MUDr. Vlastimil Válek, CSc. Fakultní nemocnice Brno RNDr. Tomáš Pavlík, Ph.D. RNDr. Ondřej Májek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno Mgr. Michal Burger Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha Mgr. Jakub Gregor, Ph.D. Mgr. Jana Koptíková, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno RNDr. Jan Mužík, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha 3 Doporučení pro léčbu sarkomů měkkých tkání Evropské společnosti klinické onkologie, ESMO MUDr. Kateřina Kubáčková Onkologická klinika 2. LF UK a FN Motol, Praha 3 Novinky v hormonální léčbě karcinomu prsu před a po ASCO 2014 prof. MUDr. Luboš Petruželka, CSc. MUDr. Zuzana Ušiaková MUDr. Michal Vočka MUDr. Lucie Hussarová Onkologická klinika 1. LF UK a VFN v Praze a Ústřední vojenská nemocnice Vojenská fakultní nemocnice Praha, Ústav radiační onkologie Nemocnice Na Bulovce v Praze 3 Antracykliny v první linii léčby karcinomu prsu mohou být účinnější, než si myslíme kazuistika doc. MUDr. Petra Tesařová, CSc. Onkologická klinika 1. LF UK a VFN v Praze 4 Nemalobuněčný karcinom plic novinky v léčbě prof. MUDr. Jana Skřičková, CSc. MUDr. Ondřej Venclíček MUDr. Bohdan Kadlec, Ph.D. MUDr. Marcela Tomíšková MUDr. Lenka Jakubíková, Ph.D. Jana Špaldová Klinika nemocí plicních a tuberkulózy LF MU a FN Brno 4 Nemalobuněčný karcinom plic s přestavbou genu EML4-ALK nové možnosti léčby prof. MUDr. Miloš Pešek, CSc. Klinika tuberkulózy a respiračních nemocí FN Plzeň prof. Dr. med. Michael Hilker, FETCS Universitätsklinikum Regensburg, Německo RNDr. Petr Grossmann FN Plzeň, Šiklův patologicko-anatomický ústav Plzeň 5 Možnosti systémové léčby gastroenteropankreatických neuroendokrinních tumorů MUDr. Jiří Tomášek, Ph.D. Klinika komplexní onkologické péče MOÚ Brno, LF MU, Brno 5 Gastrointestinální stromální tumor základní algoritmus diagnostiky a léčby MUDr. Zdeněk Linke Onkologická klinika FN Motol a 2. LF UK, Praha 6 Výběr optimální sekvence v léčbě metastatického renálního karcinomu MUDr. Hana Študentová Onkologická klinika FN Olomouc 6 Karcinom ovaria současnost a novinky v léčbě MUDr. Josef Chovanec, Ph.D. Oddělení gynekologické onkologie, MOÚ Brno 6 Stanovení strategie léčby u metastatického melanomu MUDr. Eugen Kubala Klinika onkologie a radioterapie LF UK a FN Hradec Králové 7 Role parenterální výživy v podpůrné onkologické léčbě nový pohled MUDr. Petr Beneš Interní oddělení, Nemocnice Na Homolce, Praha 7 Novinky v léčbě průlomové bolesti 7 Qutenza v léčbě chemoterapií indukované polyneuropatie 7 HPV infekce u mužů doc. MUDr. Tomáš Fait, Ph.D. Gynekologicko-porodnická klinika 1. LF UK a VFN Praha

Predikce incidence a prevalence nádorových onemocnění a počtu léčených onkologických pacientů v ČR v letech 2015 a 2020 doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha RNDr. Tomáš Pavlík, Ph.D. RNDr. Ondřej Májek, Ph.D. Mgr. Jakub Gregor, Ph.D. IBA, LF MU, Brno RNDr. Jan Mužík, Ph.D. IBA, LF MU, Brno, ÚZIS ČR, Praha RNDr. Denisa Malúšková Mgr. Jana Koptíková, Ph.D. Mgr. Zbyněk Bortlíček IBA, LF MU, Brno prof. MUDr. Jitka Abrahámová, DrSc. Thomayerova nemocnice, Praha 1 Curado, M. P. Edwards, B. Shin, H. R., et al. (eds.): Cancer incidence in five continents, roč. IX. IARC Scientific Publications č. 160. International Agency for Research on Cancer, Lyon, 2007, vyhledáno 8. 5. 2014, dostupné z: http://ci5.iarc.fr. 2 Ferlay, J. Soerjomataram, I. Ervik, M., et al.: GLOBOCAN 2012 v1.0, cancer incidence and mortality eorldwide: IARC CancerBase č. 11 [internet]. International agency for research on cancer, Lyon, 2013. Vyhledáno 5. 6. 2014, dostupné z: http://globocan.iarc.fr. 3 Dušek, L. Mužík, J. Kubásek, M., et al.: Epidemiology of malignant tumors in the Czech Republic [internet]. Masaryk University, Brno, 2005, vyhledáno 8. 5. 2014, dostupné z: http://www.svod.cz. 4 Clerc, L. Jooste, V. Lejeune, C., et al.: Cost of care of colorectal cancers according to health care patterns and stage at diagnosis in France. Eur J Health Econ, 2008, 9, s. 361 367. 5 Pavlík, T. Májek, O. Mužík, J., et al.: Estimating the number of colorectal cancer patients treated with anti-tumour therapy in 2015: the analysis of the Czech National Cancer Registry. BMC Public Health, 2012, 12, s. 117. 6 Maddams, J. Utley, M. Miller, H.: Projections of cancer prevalence in the United Kingdom, 2010 2040. Br J Cancer, 2012, 107, s. 1195 1202. 7 Mariotto, A. B. Yabroff, K. R. Sbal, Y., et al.: Projections of the cost of cancer care in the United States: 2010 2020. J Natl Cancer Inst, 2011, 103, s. 117 128. 8 Travis, L. B.: The epidemiology of second primary cancers. Cancer Epidemiol Biomarkers Prev, 2006, 15, s. 2020 2026. Predikce počtu pacientů indikovaných k vyšetření PET/CT v ČR: první výsledky projektu PET/CT-CZ (Q) doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha prof. MUDr. Jiří Petera, Ph.D. doc. MUDr. Jiří Doležal, Ph.D. Fakultní nemocnice Hradec Králové prof. MUDr. Vlastimil Válek, CSc. Fakultní nemocnice Brno RNDr. Tomáš Pavlík, Ph.D. RNDr. Ondřej Májek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno Mgr. Michal Burger Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha Mgr. Jakub Gregor, Ph.D. Mgr. Jana Koptíková, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno RNDr. Jan Mužík, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha 1 Dušek, L. Mužík, J. Kubásek, M. Koptíková, J. Žaloudík, J. Vyzula R.: SVOD.cz Epidemiologie zhoubných nádorů v České republice (internetová stránka). Masarykova univerzita, 2007, vyhledáno 3. 7. 2014, dostupné na www.svod.cz. 2 Ferlay, J. Autier, P. Boniol, M. Heanue, M. Colombet, M. Boyle, P.: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol, 2007, 18, s. 581 592. 3 Ferlay, J. Steliarova-Foucher, E. Lortet-Tieulent, J. Rosso, S. Coebergh, J. W. Comber, H., et al.: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer, 2013, 49, s. 1374 1403. 4 Dyba, T. 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(eds.): Data and knowledge for medical decision support: Proceedings of the EFMI special topic conference, 17-19 April 2013, Prague, Czech Republic: IOS Press; 2013. 15 Pavlík, T. Májek, O. Mužík, J., et al.: Estimating the number of colorectal cancer patients treated with anti-tumour therapy in 2015: the analysis of the Czech National Cancer Registry. BMC Public Health, 2012, 12, s. 117.

Doporučení pro léčbu sarkomů měkkých tkání Evropské společnosti klinické onkologie, ESMO MUDr. Kateřina Kubáčková Onkologická klinika 2. LF UK a FN Motol, Praha 1 ESMO/European Sarcomas Network Working Group. Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 2012, 23 (7), s. vii92 vii99. Novinky v hormonální léčbě karcinomu prsu před a po ASCO 2014 prof. MUDr. Luboš Petruželka, CSc. MUDr. Zuzana Ušiaková MUDr. Michal Vočka MUDr. Lucie Hussarová Onkologická klinika 1. LF UK a VFN v Praze a Ústřední vojenská nemocnice Vojenská fakultní nemocnice Praha, Ústav radiační onkologie Nemocnice Na Bulovce v Praze 1 ASCO Annual Meeting Abstracts, 30. května 3. června 2014. 2 Bachelot, T., et al.: Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. J Clin Oncol, 2012, 30, s. 2718 2724. 3 Baselga, J., et al.: Everolimus in postmenopausal hormone-receptor- -positive advanced breast cancer. N Engl J Med, 2012. 4 Di Leo, A. Jerusalem, G. Petruzelka, L., et al.: Results of the CON- FIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. J Clin Oncol, 2010. 5 Jones, S. E., et al.: Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. J Clin Oncol, 2005. 6 Kaufman, B., et al.: Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study. J Clin Oncol, 2009. 7 Ellis, M. J., et al.: Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature, 2012. 8 Finek, J. Petruželka, L., et al.: První česko-moravský konsensus hormonální léčby karcinomu prsu. 2014 (v přípravě k tisku). 9 Finn, R. S., et al.: PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res, 2009. 10 Finn, R. S., et al.: Final results of a randomized Phase II study of PD 0332991, a cyclin-dependent kinase (CDK)-4/6 inhibitor, in combination with letrozole vs. letrozole alone for first-line treatment of ER+/ HER2- advanced breast cancer (PALOMA-1; TRIO-18). AACR, abstrakt CT101, 2014. 11 Giordano, S. H., et al.: Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol, 2014. 12 Hober, J., et al.: Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer results of the electra trial. Breast, 2012. 13 Jerusalem, G., et al.: Safety analysis of BOLERO-3: a phase 3 trial of daily everolimus (EVE) vs. placebo (PBO), both with weekly trastuzumab (TRAS) and vinorelbine in trastuzumab-resistant, advanced breast cancer. San Antonio Breast Cancer Symposium; abstrakt S2-02, 2013. 14 Lee, A. V. Davidson, N. E.: Genomics, drug approval, and optimal treatment duration. Nat Rev Clin Oncol, 2014. 15 Martin, M., et al.: S1-7. Phase III trial evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for advanced breast cancer First efficacy results from the LEA study. Cancer Res, 2012. 16 Montemurro, M., et al.: Humen epidermal growth factor receptor 2 (HER2) positive and hormone receptor-positive breast cancer: new insights into molecular interactions and clinical implications. Ann Oncol, 2013. 17 Palmieri, C., et al.: Breast cancer: Current and future endocrine therapies. Molecular and Cellular Endocrinology, 2014. 18 Petruželka, L. Vočka, M. Matějů, M.: Metastazující hormonálně dependentní karcinomy prsu doporučené postupy nebo jen obecné léčebné principy ve světle nových poznatků? 2014. 19 Piccart, M., et al.: Everolimus for postmenopausal women with advanced breast cancer: updated results of the BOLERO-2 phase III trial [abstrakt 559]. J Clin Oncol, 2012. 20 Piccart, M., et al.: Everolimus plus exemestane for hormone receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2-) advanced breast cancer (BC): overall survival results from BOLERO-2. Přednáška, abstrakt LBA1. European Breast Cancer Conference (EBCC-9), 2014. 21 Swain, S. M., et al.: Pertuzumab, trastuzumab, and docetaxel for HER2- -positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol, 2013. 22 Seidman, A. D., et al.: Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: Final results of Cancer and Leukemia Group B protocol 9840. J Clin Oncol, 2008. 23 Schwartzberg, L. S., et al.: Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer. Oncologist, 2010. 24 Yardley, D. A., et al.: Results of ENCORE 301, a randomized, phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive (ER+) breast cancer progressing on a nonsteroidal aromatase inhibitor (AI). J Clin Oncol, 2013. 25 Yardley, D. 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Nemalobuněčný karcinom plic novinky v léčbě prof. MUDr. Jana Skřičková, CSc. MUDr. Ondřej Venclíček MUDr. Bohdan Kadlec, Ph.D. MUDr. Marcela Tomíšková MUDr. Lenka Jakubíková, Ph.D. Jana Špaldová Klinika nemocí plicních a tuberkulózy LF MU a FN Brno 1 Dušek, L. Májek, O. Mužík, J. Kostíková, J. Pavlík, T. Skřičková, J.: Epidemiologie zhoubných nádorů plic, průdušnice a průdušek v ČR. In: Skřičková, J. Kolek, V., et al.: Základy moderní pneumoonkologie. Maxdorf, Praha, 2012. 2 Giroux, D. J. Rami-Porta, R. Chansky, K., et al.: The IASLC Lung Cancer Staging Project: data elements for the prospective project. J Thorac Oncol, 2009, 4, s. 679 83. 3 Pešek, M.: Nemalobuněčný karcinom plic. EUNI, dostupné z: http:// www.euni.cz/tema.php?, vyhledáno 22. 9. 2014. 4 Škarda, J. Überall, I. Tichý, T. Matěj, R.: Novinky v klasifikaci adenokarcinomů plic a potenciální prognostické a prediktivní faktory u nemalobuněčných plicních karcinomů. Cesk Patol, 2011, 47, s. 168 172. 5 Travis, W. D. 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BMC Cancer, 2012, 12, s. 107. 24 ENESTg1: A randomized, open-label, multi-center phase III study to evaluate the efficacy and safety of nilotinib versus imatinib in adult patients with unresectable or metastatic gastrointestinal stromal tumor (GIST). http://clinicaltrials.gov/show/nct00785785. 25 An open-label, multi-center, single arm study to evaluate the efficacy of nilotinib in adult patients with metastatic or unresectable gastrointestinal stromal tumors in first line treatment. http://clinicaltrials. gov/ct2/show/nct00756509. 26 Randomized phase III trial comparing nilotinib 800 mg imatinib 800 mg for the treatment of patients with advanced and/or metastatic gastrointestinal stromal tumor refractory to imatinib 400 mg. http:// clinicaltrials.gov/ct2/show/nct00751036. 27 A phase II, non-randomized, open-label multicenter study of 5 years adjuvant imatinib mesylate (Gleevec ) in patients at significant risk of recurrence following complete resection of primary gastrointestinal stromal tumor (GIST). http://clinicaltrials.gov/ct2/show/ NCT00867113. 28 A phase II, open-label study of PTK787/ZK222584 in the treatment of metastatic gastrointestinal stromal tumors (GIST) resistant to imatinib mesylate. http://clinicaltrials.gov/ct2/show/study/nct00117299. 29 Phase 2 study of oral AB1010 in non pre-treated, inoperable patients with locally advanced / metastatic gastro-intestinal stromal tumor (GIST). http://clinicaltrials.gov/ct2/show/nct00998751. 30 An open-label study of AMG 706 in subject with advanced gastrointestinal stromal tumors (GISTs) who developed progressive disease or relapsed while on imatinib mesylate. http://clinicaltrials.gov/ct2/ show/nct00089960. 31 An open-label, phase II study to evaluate the biological activity of cediranib (AZD2171) as measured by (F 18) fluoro 2 deoxy d glucose positron emission tomography (FDG-PET) response, in patients with metastatic gastro-intestinal stromal tumors (GISTs) resistant or intolerant to imatinib mesylate. http://clinicaltrials.gov/ct2/show/ study/nct00385203. 32 An phase II study of sorafenib in patients with metastatic or advanced gastrointestinal stromal tumors (GISTs) who failed to imatinib and sunitinib. http://clinicaltrials.gov/ct2/show/nct01091207. 33 A study evaluating STA-9090 in patients with metastatic and/or unresectable gastrointestinal stromal tumors (GIST). http://clinicaltrials. gov/ct2/show/nct010339519. 34 Dasatinib first-line treatment in gastrointestinal stromal tumors. A multi center phase II trial. http://clinicaltrials.gov/ct2/show/ NCT00568750. 35 Phase II study of crenolanib (CP-868,596), a selective and potent inhibitor of PDGFR, for the treatment of patients with advanced gastrointestinal stromal tumors with the D842-related mutations and deletions, including the D842V mutation, in the PDGFRA gene. http:// clinicaltrials.gov/ct2/show/nct01243346. 36 A study evaluating the safety, tolerability and pharmacokinetics of GDC-0973 in combination with GDC-0941 when administered daily in patients with locally advanced or metastatic solid tumor. http:// clinicaltrials.gov/ct2/show/nct0133184. 37 A study evaluating GDC-0980 administered once daily in patients with refractory solid tumors or non-hodgkin s lymphoma. http://clinicaltrials.gov/ct2/show/nct000997765.

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