Final Report on the Realization of the Large Research, Experimental Development and Innovation Infrastructure (LI) BBMRI_CZ

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1 Final Report on the Realization of the Large Research, Experimental Development and Innovation Infrastructure (LI) BBMRI_CZ Full name of the LI: BBMRI_CZ project within the Czech part of Large Distributed Research Infrastructure of pan-european significance: establishment and operation of the network of biobanks for biomedical research LI s code: LM Recipient: Masaryk Memorial Cancer Institute Another participant/s of the LI: FM1 CU Prague, FM CU Hradec Králové, FM CU Plzeň, FM PU Olomouc Principal investigator of the LI: Assoc. professor MUDr. Dalibor Valík, Ph.D. Resolution of the Government of the day, number: March 15, 2010 no. 208 Financing period: ; Decision Ref. no / A. Overall Assessment of the Realization of the LI Briefly describe the course of the realization of the LI for the entire financial period, describe and assess the achieved objectives and results of the LI. The extent of 2-5 A4 pages. The mission and major goals of the LI: To establish and operate the network of research biobanks affiliated to medical faculties and specialized institutions in the Czech Republic that will store biological samples of cancer patients in the long-term way under the coordination of the Biobank at MMCI, which would be otherwise lost for medical research. Starting point: Due to the exponential growth of the aging population, healthcare is facing increased incidence of cancer and chronic diseases. Public health constitutes a challenge for the origin of advanced technologies and devices that will improve diagnostics, prevention and disease treatment leading to a progress towards personalized medicine. The advantage of such technologies can be fully taken only at the accessibility of comprehensive collections of human tissues, cells, body fluids and related clinical data. The infrastructure of BBMRI_CZ biobanks was strictly proposed for biological and medical research purposes. Note: The BBMRI_CZ biobanking system is a different type of repository compared to the bank of biologic material intended for storage of tissues for commercial and therapeutic purposes, such as cadaver tissue repositories, blood banks, engineered tissues, core blood banks etc. as specified in ( and Czech legislation. The period before the start of the project until 2010: In the Czech Republic: The history of biobanking in MMCI reaches back up to the fifties when prof. 1 z 55

2 Brada was a key person for systematic collecting of human tissue samples and body fluids. Biological samples were stored ad hoc according to the interests or specialization of particular researchers (blood, cells, specific biological liquids, tissues, etc.). Formally, the biobank at MMCI has been established in 2001 from the institutional funds. In 2010 the cooperation with CERIT SC centre in the IT field has been initiated, (assoc. professor Petr Holub, Ph.D). The milestone: The decision of MEYS on supporting the project was issued on the 7 th of October Abroad: The significant preparatory activity at the international field has lead to the BBMRI-CZ Associate Membership on the 22 nd October 2009, i.e. one year before BBMRI_CZ project initiation. MMCI has presented BBMRI_CZ at a number of international forums during the year 2010 (Brussels, European Parliament Hearing Dr. Paul Rübig MEP, Chairman of STOA and member of the ITRE Committee, hearing on the 26 th of October, 2010) and other activities In the Czech Republic: an agreement of FM1 CU a MF HK as participants in BBMRI_CZ network signed on the 21 st of September Abroad: preparations for BBMRI-ERIC founding continued, we (BBMRI_CZ) were actively participating in negotiations on BBMRI-ERIC Preparatory Phase Steering Committee In the Czech Republic: of MF PU OL as participant on the 21 st of May Abroad: The presentation of the project during the official visit in Azerbaijan, Baku; regular participation at meetings of the Preparatory Body BBMRI-ERIC. Setting the conditions for call announcement for the position of Director General of BBMRI-ERIC was the primary activity during the year In the Czech Republic: The implementation of biobanking activities within participating institutions laying emphasis on IT activities. Abroad: The Czech Republic participates as a founding member in the provision of BBMRI-ERIC, COMMISSION IMPLEMENTING DECISION of the 22th of November 2013 on setting up the Biobanks and Biomolecular Resources Research Infrastructure Consortium (BBMRI-ERIC) as a European Research Infrastructure Consortium (2013/701/EU), i.e. a key milestone of BBMRI activities is fulfilled. The project and its status were presented by the national coordinator at the BBMRI PP meeting in Amsterdam on the 10 th of February 2013 and at the kick-off meeting of BBMRI-ERIC in Graz on the 15 th of September In the Czech Republic: an agreement of FM CU Plzeň as participant on the 29 th of October The implementation activities within particular participating institutions carry on as well as the preparation of BBMRI_CZ materials for the financial period A comprehensive study on the BBMRI_CZ project development and its interconnection towards clinical research infrastructures such as ECRIN and EATRIS was prepared for this purpose. Internationalisation - the activities within BBMRI-ERIC: as a founding member of the BBMRI-ERIC consortium, we have the duty to participate in periodic meetings of Management Committee BBMRI-ERIC and AoM BBMRI-ERIC at the same time, the Czech representative is Petr Ventulka from MEYS. We presented activities of the Czech part of BBMRI-ERIC at a number of international 2 z 55

3 meetings (Berlin, Graz). The assoc. professor Petr Holub aspired on the position of the director of IT Services BBMRI-ERIC; he was approved in the second half of In the Czech Republic: the expansion of clinical biobanking activities in particular participant institutions. The preparation for the period following 2016 consisting of stronger involvement of the host institutions and participating university hospitals. Internationalisation: analogously to 2014 we participated in BBMRI-ERIC operations and activities, i.e. management committees and AoM, specific and expert meetings and conferences, in 2015 HandsOnBiobank (Milano, July 2015) was the most significant achievement. The significant implementation of BBMRI-ERIC IT infrastructure resulted in the involvement of BBMRI_CZ in BBMRI-ERIC provided IT services as CS-IT. Concurrently, BBMRI_CZ was involved in CS-ELSI. Owing to international contacts, BBMRI_CZ started to participate in the realization of the ADOPT BBMRI- ERIC project and in the EGI-ENGAGE project through the cooperation with European e- infrastructures EGI and EUDAT. Summary: the infrastructure of clinical biobanks focusing on cancer research is established at the end of financial period. This infrastructure represents a functional entity of cooperating subjects with a stated structure of users and an international anchoring. Fig. 1. The aim of the project (left figure, year 2010), i.e. to establish and operate the network of research biobanks affiliated to medical faculties and specialized institutions in the Czech Republic that will store biological samples of cancer patients in the long-term way under the coordination of Biobank at MMCI, which would be otherwise lost for medical research, was accomplished (right figure, year 2015). 3 z 55

4 B. LI s Management Structure and Research Team I. Describe the management structure and organizational chart of the LI (eventually its changes during the financial period) and its anchorage within the host institution / host institutions. Indicate the composition and possible changes in the external advisory bodies (both scientific and management specialization). II. Describe the LI s plan for human resources development. Indicate the members of LI s research team for the entire financial period (all persons paid from personnel costs chapter of the LI), briefly indicate their job description and classification, including their full-time equivalent (lowest, highest and average), employment period and overall financial costs, further differentiate the permanent (core employees) and temporary staff (employees that have signed agreements on work performed outside employment). All the participant institutions, MMCI, FM1 CU Prague, FM CU Hradec Králové, FM CU Plzeň, PU Olomouc, have supported the establishment of BBMRI research infrastructure and currently they are actively participating in its operation. It would be impossible to realize all the steps necessary for establishing of BBMRI_CZ without the direct participation of partner institutions. The indispensable parts of research infrastructure are university hospitals with their diagnostic departments and standard operating procedures. MMCI is as a beneficiary and the national coordinator the only legal entity within the Czech legislation that is authorized to realize all the legal operations. The faculties of medicine act within the respective universities. University hospitals dispose its own legal capacities and thus the relations between faculties of medicine and university hospitals follow respective agreements. MEYS is informed concenrning all the contracts in annual reports. Partner institution support consists chiefly in the construction of facilities with common instrumentation and in providing a highly qualified staff. The following scheme (Fig. 2) describes the organizational relationships and responsibilities within BBMRI_CZ: MMCI is as a beneficiary represented by the director of the Institute that carries out the statutory operations for BBMRI_CZ. MMCI director is superior to the RECAMO executive director, which is the national coordinator of BBMRI_CZ. The national coordinator manages the activities of the heads of biobanks and partner institutions. As follows from the organizational scheme all the necessary operations are realized by the management of individual institutions. The organizational scheme of partner institutions has the same characteristics, however they may reflect local conditions, i.e. the specifics of individual medical faculty and university hospital (personal, IT services, the sharing of facilities and instumentation, etc.). 4 z 55

5 Fig. 2. The scheme of organizational relationships and responsibilities within BBMRI_CZ. Refered to II. It is included in respective periodic reports; Human resources: as the project financing is rather booster financing than sustainable financing, moreover it is cyclically bound to the assignment of project finances, the equilibrium state is represented by transferring as much as possible of FTEs into the structure of the participating institution, i.e. the employees of required specialization contribute by added value within their working activities. This fulfills the overall aim of BBMRI_CZ to increase significantly the involvement of the healthcare resort in these activities. C. Outcomes of the LI I. Indicate the scientific results achieved by the LI s research team on the basis of the LI s use for the entire period. Individual results indicate according to valid methodology of CRDI (Council for Research, Development and Innovation), if possible J type results complete with impact factor according to WoK or Scopus. Among these results specify 20 most important ones. II. Indicate the main scientific results (not more than 20) achieved on the basis of the LI s use (its Czech branch in case of distributed research infrastructures) by its users, if it is possible to attest. Individual results indicate according to valid methodology of CRDI, if possible J type results complete with impact factor according to WoK or Scopus. I. Research results achieved by the research team based on the utilizing the LI 1) Results utilizing the infrastructure and dedicated to LM a) Publications in journals with impact factor (J imp ) 1. Bauerová, L., Dundr, P., Fischerová, D., Pešl, M., Zikán, M., Burgetová, A. Ovarian metastasis of clear cell renal cell carcinoma: A case report. Can Urol Assoc J 2014;8(3-4):E188-E192. (IF2013: 1,92) 2. Bencsikova, B., Bortlicek, Z., Halamkova, J., Ostrizkova, L., Kiss, I., Melichar, B., Pavlik, T., Dusek, L., Valik, D., Vyzula, R., Zdrazilova-Dubska, L. Efficacy of bevacizumab and chemotherapy in the first-line treatment of metastatic colorectal cancer: broadening 5 z 55

6 KRAS-focused clinical view. BMC Gastroenterol 2015;15:37. (IF2014: 2,365) 3. Bouchal, P., Dvořáková, M., Roumeliotis, T., Bortlíček, Z., Ihnatová, I., Procházková, I., Ho, J.T.C., Maryáš, J., Imrichová, H., Budinská, E., Vyzula, R., Garbis, S.D., Vojtěšek, B., Nenutil, R. Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κb (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer. Mol Cell Proteomics 2015;14(7): (IF2014: 6,564) 4. Croce, S., Ribeiro, A., Brulard, C., Noel, J.C., Amant, F., Stoeckle, E., Devouassoux- Shisheborah, M., Floquet, A., Arnould, L., Guyon, F., Mishellany, F., Garbay, D., Cuppens, T., Zikan, M., Leroux, A., Frouin, E., Duvillard, P., Terrier, P., Farre, I., Valo, I., MacGrogan, G.M., Chibon, F. Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. Mod Pathol 2015;28(7): (IF 6.187) 5. Čermáková, P., Melichar, B., Tomšová, M., Zoul, Z., Kalábová, H., Špaček, J., Doležel, M. Prognostic Significance of CD3+Tumor-infiltrating Lymphocytes in Patients with Endometrial Carcinoma. Anticancer Res 2014;34(10): (IF2013: 1,872) 6. Dobes, P., Podhorec, J., Coufal, O., Jureckova, A., Petrakova, K., Vojtesek, B., Hrstka, R. Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients. Oncol Rep 2014;32: (IF2013: 2,191) 7. Dudakova L, Palos M, Jirsova K, Dundr P, Liskova P. Clinical and histopathological findings in a patient with p.(leu558arg) mutation in the TGFBI gene. Ophtalmic Genetics 2015 (accepted) (IF 1.445) 8. Dudakova L, Sasaki T, Liskova P, Palos M, Jirsova K. The presence of lysyl oxidase-like enzymes in human control and keratoconic corneas. Histol Histopathol 2016;31(1): (IF 2.096) 9. Faltejskova, P., Besse, A., Sevcikova, S., Kubiczkova, L., Svoboda, M., Smarda, J., Kiss, I., Vyzula, R., Slaby, O. Clinical correlations of mir-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells. Int J Colorectal Dis 2012;27(11): (IF2011: 2,385) 10. Faltejskova, P., Svoboda, M., Srutova, K., Mlcochova, J., Besse, A., Nekvindova, J., Radova, L., Fabian, P., Slaba, K., Kiss, I., Vyzula, R., Slaby, O. Identification and functional screening of micrornas highly deregulated in colorectal cancer. J Cell Mol Med 2012;16(11): (IF2011: 4,125) 11. Fedorko, M., Stanik, M., Iliev, R., Redova-Lojova, M., Machackova, T., Svoboda, M., Pacik, D., Dolezel, J., Slaby, O. Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma. Int J Mol Sci 2015;16(10): (IF2014: 2,862) 12. Franková V, Jirsová K, Zima T. The Bank of Biological Material (BBM) of the First Faculty of Medicine of Charles University in Prague, Czech Republic. Biopreserv Biobank 2015;13(4): (IF 1.340) 13. Hezova, R., Kovarikova, A., Srovnal, J., Zemanova, M., Harustiak, T., Ehrmann, J., Hajduch, M., Sachlova, M., Svoboda, M., Slaby, O. MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus. Tumour Biol [Epub ahead of print] (IF2014: 3,611) 14. Hezova, R., Kovarikova, A., Bienertova-Vasku, J., Sachlova, M., Redova, M., Vasku, A., Svoboda, M., Radova, L., Kiss, I., Vyzula, R., Slaby, O. Evaluation of SNPs in mir-196-a2, mir-27a and mir-146a as risk factors of colorectal cancer. World J Gastroenterol 6 z 55

7 2012;18(22): (IF2011: 2,471) 15. Hrstka, R., Murray, E., Brychtova, V., Fabian, P., Hupp, T.R., Vojtesek, B. Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2. Cancer Lett 2013;333(2): (IF2012: 4,258) 16. Iliev R, Stanik M, Fedorko M, Poprach A, Vychytilova-Faltejskova P, Slaba K, Svoboda M, Fabian P, Pacik D, Dolezel J, Slaby O. Decreased expression levels of PIWIL1, PIWIL2, and PIWIL4 are associated with worse survival in renal cell carcinoma patients. Oncotargets Ther 2016;9: (IF2014: 2,311) 17. Kalousová, M., Krechler, T., Jáchymová, M., Kuběna, A.A., Zák, A., Zima, T. Ferritin as an independent mortality predictor in patients with pancreas cancer. Results of a pilot study. Tumour Biol 2012;33(5): (IF2011: 2,143) 18. Karbanová, J., Laco, J., Marzesco, A., Janich, P., Voborníková, M., Mokrý, J., Fargeas, Ch.A., Huttner, W.B., Corbeil, D. Human PROMININ-1 (CD133) Is Detected in Both Neoplastic and Non-Neoplastic Salivary Gland Diseases and Released into Saliva in a Ubiquitinated Form. PLoS ONE 2014;9(6):e (IF2014: 3,234) 19. Koudeláková, V., Berkovcová, J., Trojanec, R., Vrbková, J., Radová, L., Ehrmann, J., Kolář, Z., Melichar, B., Hajdúch, M. Evaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR Method. Journal of Molecular Diagnostic 2015;17(4): (IF2013: 3,955) 20. Laco, J., Podhola, M., Kamarádová, K., Novák, I., Dobeš, D., Broďák, M., Hácová, M., Ryška, A. Idiopathic vs. secondary retroperitoneal fibrosis: a clinicopathological study of 12 cases, with emphasis to possible relationship to IgG4-related disease. Virchows Arch 2013;463(5): (IF2012: 2,676) 21. Laco J., Kamarádová K., Mottl R., Mottlová A., Doležalová H., Tuček L., Žatečková K., Slezák R., Ryška A. Plasma cell granuloma of the oral cavity - a mucosal manifestation of immunoglobulin G4-related disease or a mimic? Virchows Arch 2015;466(3): (IF: 2,560) 22. Laco J., Örhalmi J., Bártová J., Zimandlová D. Enterocolic lymphocytic phlebitis as a newly recognized manifestation of IgG4-related disease. Int J Surg Pathol 2015;23(2): (IF: 0,961) 23. Laco, J., Sieglová, K., Vošmiková, H., Dundr, P., Němejcová, K., Michálek, J., Čelakovský, P., Chrobok, V., Mottl, R., Mottlová, A., Tuček, L., Slezák, R., Chmelařová, M., Sirák, I., Vošmik, M., Ryška, A. The presence of high-risk human papillomavirus (HPV) E6/E7 mrna transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis. Virchows Arch 2015;467(4): (IF: 2,651) 24. Lukáš, J., Drábek, J., Dudešek, B., Vážan, P., Stránská, J., Jančík, S., Macková, M., Syrůček, M., Lukáš, D., Dušková, J., Dundr, P., Hintnausová, B., Jiskra, J. Correlation among the BRAF Gene Mutation Status, Clinicopathological Features of Primary Tumour, and Lymph Node Metastasizing of Papillary Thyroid Carcinoma. Exp Clin Endocr Diab 2014;122(5): (IF2013: 1,76) 25. Merhautova, J., Hezova, R., Poprach, A., Kovarikova, A., Radova, L., Svoboda, M., Vyzula, R., Demlova, R., Slaby, O. mir-155 and mir-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib. Biomed Res Int 2015;2015: (IF2014: 1,579) 26. Němejcová K., Kenny S.L., Laco J., Škapa P., Staněk L., Zikán M., Kleiblová P., McCluggage 7 z 55

8 W.G., Dundr P. Atypical polypoid adenomyoma of the uterus: an immunohistochemical and molecular study of 21 cases. Am J Surg Pathol 2015;39(8): (IF: 4,592) 27. Němejcová, K., Cibula, D., Dundr, P. Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases. Diagn Pathol 2015;10:8. (IF 2.60) 28. Němejcová, K., Tichá, I., Kleiblová, P., Bártů, M., Cibula, D., Jirsová, K., Dundr, P. Expression, epigenetic and genetic changes of HNF1B in endometrial lesions. Pathol Oncol Res 2015 Dec 19. [Epub ahead of print] (IF 1.855) 29. Obermannova, R., Dusek, L., Greplova, K., Jarkovsky, J., Sterba, J., Vyzula, R., Demlova, R., Zdrazilova-Dubska, L., Valik, D. Time-course pattern of blood 25-hydroxycholecalciferol is a significant predictor of survival outcome in metastatic colorectal cancer: a clinical practice-based study. Neoplasma 2015;62(6): (IF2014: 1,865) 30. Omran, N., Laco, J., Krbal, L., Vojáček, J., Manďák, J. Isolated Thoracic Aortitis. J Cardiac Surg 2014;29(2): (IF2013: 0,888) 31. Reichl, P., Fang, M., Starlinger, P., Staufer, K., Nenutil, R., Muller, P., Greplova, K., Valik, D., Dooley, S., Brostjan, C., Gruenberger, T., Shen, J., Man, K., Trauner, M., Yu, J., Gao, C.F., Mikulits, W. Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma. Int J Cancer 2015;137(2): (IF2014: 5,085) 32. Redova, M., Poprach, A., Besse, A., Iliev, R., Nekvindova, J., Lakomy, R., Radova, L., Svoboda, M., Dolezel, J., Vyzula, R., Slaby, O. MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma. Tumour Biol 2013;34(1): (IF2012: 2,518) 33. Redova, M., Poprach, A., Nekvindova, J., Iliev, R., Radova, L., Lakomy, R., Svoboda, M., Vyzula, R., Slaby, O. Circulating mir-378 and mir-451 in serum are potential biomarkers for renal cell carcinoma. J Transl Med 2012;10:55. (IF2011: 3,474) 34. Slaby, O., Redova, M., Poprach, A., Nekvindova, J., Iliev, R., Radova, L., Lakomy, R., Svoboda, M., Vyzula, R. Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients. Genes Chromosomes Cancer 2012;51(7): (IF2011: 3,306) 35. Staněk, L., Rozkoš, T., Laco, J., Ryška, A., Petruželka, L., Důra, M., Dundr, P. Comparison of immunohistochemistry, four in situ hybridization methods and quantitative polymerase chain reaction for the molecular diagnosis of HER2 status in gastric cancer: A study of 55 cases. Mol Med Rep 2014;10(5): (IF2013: 1,484) 36. Šteiner, I., Špaček, J., Matějková, A., Vojáček, J., Bis, J., Dušek, J. Histopathology of aspirated thrombi during primary percutaneous coronary intervention in patients with acute myocardial infarction. Cardiovasc Pathol 2014;23(5): (IF2013: 2,336) 37. Šteiner, I., Vojáček, J. Carcinoma embolization in coronary artery causing myocardial infarction Diagnosis from coronary thromboaspirate. Pathol Res Pract 2014;210(3): (IF2013: 1,562) 38. Thorenoor, N., Faltejskova-Vychytilova, P., Hombach, S., Mlcochova, J., Kretz, M., Svoboda, M., Slaby, O. Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget [Epub ahead of print] (IF2014: 6,359) 39. Vítek, L. Serum bilirubin levels and the risk of Crohn's disease. J Crohns Colitis 2012;6(6):732; author reply 733. (IF2011: 2,566) 40. Zapletalova, D., André, N., Deak, L., Kyr, M., Bajciova, V., Mudry, P., Dubska, L., Demlova, 8 z 55

9 R., Pavelka, Z., Zitterbart, K., Skotakova, J., Husek, K., Martincekova, A., Mazanek, P., Kepak, T., Doubek, M., Kutnikova, L., Valik, D., Sterba, J. Metronomic Chemotherapy with the COMBAT Regimen in Advanced Pediatric Malignancies: A Multicenter Experience. Oncology 2012;82(5): (IF2011: 2,267) b) Publications in reviewed journals without impact factor (J rec ) 1. Bencsiková, B. Perioperační chemoterapie a neadjuvantní léčba lokálně pokročilých nádorů žaludku a gastroezofageální junkce. Onkologická Revue 2015;září 2015: ISBN Brychtová, V., Vojtěšek. B. Detekce proteinů, proteinových interakcí a modifikací s využitím proximity ligation assay in situ. Klin Onkol 2014;27(Suppl1):S87 S Coufalová, D., Vojtěšek, B., Hernychová, L. Co může přinést studium oligomerizace proteinů v procesu onkogeneze? Klin Onkol 2015;28(Suppl 2):2S6 2S Čelakovský, P., Kalfeřt, D., Chrobok, V., Laco, J.: Klinický význam a možnosti detekce mikrometastáz u dlaždicobuněčného karcinomu hlavy a krku. Otorinolaryngol. a Foniatr. /Prague/, 2013, 62, 4, s Demlová, R. Personalizovaná terapie a vývoj nových protinádorových léčiv nastal čas pro změnu klasického designu studiví fáze I-III?. Onkologická Revue 2015;září 2015: ISBN Demlova, R., Obermannova, R., Valik, D., Vyzula, R. Phase I Trial in Oncology theory and practice. Klin Onkol 2012;25(Suppl2):2S98 2S Drábová, K., Bienertová-Vašků, J., Lokaj, P., Dubská, L., Obermannová, R., Greplová, K., Demlová, R., Valík, D., Štěrba, J. Vitamin D jeho fyziologie, patofyziologie a význam v etiopatogenezi nádorových onemocnění. Čas Lék Čes 2013;152(1): DUBSKÁ, L., M. VYSKOČILOVÁ, R. NENUTIL, D. VALÍK, D. KNOFLÍČKOVÁ, P. FABIAN, I. KOCÁKOVÁ, R. DEMLOVÁ, M. BERÁNEK, M. DRASTÍKOVÁ, H. VOŠMIKOVÁ, A. BÓDAY, K. HORKÁ, J. ŠÍMOVÁ, J. DRÁBEK, J. EHRMANN ml., M. HAJDÚCH, M. MATĚJČKOVÁ, R. ŠÍMA, D. TVRDÍK, C. POVÝŠIL a A. RYŠKA. Vyšetření mutačního statutu genu KRAS jako součást algoritmu léčby metastatického kolorektálního karcinomu. Časopis lékařů českých. 2011, 150(6), ISSN Dvořák, O., Dvořáková, E., Laco, J., Špaček, J. Solitární fibrózní tumor endometria kazuistika. Čes Gynek 2013;78(3): Dvořáková, P., Nekulová, M., Holčáková, J., Vojtěšek, B., Hernychová, L. Analýza změn fosfoproteomu nádorové buněčné linie MDA- MB- 468 v odpovědi na expresi izoforem p63 pomocí hmotnostní spektrometrie Klin Onkol 2015;28(Suppl 2):2S11 2S Faktor, J., Dvorakova, M., Maryas, J., Struharova, I., Bouchal, P. Identification and characterisation of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies. Klin Onkol 2012;25(Suppl2):2S70 2S77. (no IF) 12. Faktor, J., Michalová, E., Bouchal, P. p-srm, SWATH a HRM cílené proteomické přístupy na hmotnostním spektrometru TripleTOF a jejich aplikace v onkologickém výzkumu. Klin Onkol 2014;27(Suppl1):S110 S Holub, P., Greplova, K., Knoflickova, D., Nenutil, R., Valik, D. The Biobanking Research Infrastructure BBMRI_CZ: A Critical Tool to Enhance Translational Cancer Research. Klin Onkol 2012;25(Suppl2):2S78 2S81. 9 z 55

10 14. Hornychová H., Matějková A., Kacerovský M. Practical comments on examination of placenta in the second and third trimester of gravidity. Cesk Patol 2015;51(2): (bez IF) 15. Hovorková, E., Hadži Nikolov, D., Ferko, A., Örhalmi, J., Chobola, M., Ryška, A. Problematika stanovení bezpečných resekčních okrajů u karcinomu rekta. Rozhl Chir 2014;93(2): Hrstka, R., Kolářová, T., Michalová, E., Vojtěšek, B. Vývoj metod založených na PCR a jejich aplikace v onkologickém výzkumu a praxi. Klin Onkol 2014;27(Suppl1):S69 S Chmelarova, M., Dvorakova, E., Spacek, J., Laco, J., Palicka, V. Importance of promoter methylation of GATA4 gene in epithelial ovarian cancer. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2013;157(4): Kalfeřt, D., Laco, J., Čelakovský, P., Smatanová, K., Ludvíková, M. Oncocytic Schneiderian papilloma of frontal sinus. Acta Medica (Hradec Kralove), 2013, 56, 4, s Krejčí, A., Müller, P., Vojtěšek, B. Bioinformatika a sekvenování nové generace. Klin Onkol 2015;28(Suppl 2):2S91 2S Lordick, F., Obermannová, R. Novel targets and treatment of advanced gastrin cancer: chat exists and chat comes next. Onkologická Revue 2015;září 2015: ISBN Maryáš, J., Bouchal, P. PDLIM2 a jeho role v onkogenezi tumor supresor nebo onkoprotein? Klin Onkol 2015;28(Suppl 2):2S40 2S Matějková, A., Šteiner, I. Morfologické a elektrofyziologické změny v srdečních síních zemřelých s fibrilací síní - pilotní studie. Česk Patol 2014;50-59(4): Novotný, I. Endoskopická diagnostika a léčba karcinomu žaludku. Onkologická Revue 2015;září 2015:7-14. ISBN Obermannová, R., Demlová, R., Drábová, K., Melichárková, K., Greplová, K., Mrkvicová, M., Zdražilová Dubská, L., Vyzula, R., Valík, D. Vitamin D jako významný steroidní hormon u karcinomu prsu. Klin Onkol 2014;27(Suppl1):S143 S Ondroušková, E., Hrstka, R. Cirkulující nádorová DNA v krvi a její využití jako potenciálního biomarkeru nádorových onemocnění. Klin Onkol 2015;28(Suppl 2):2S69 2S Orzol, P., Nekulova, M., Vojtesek, B., Holcakova, J. p63 - an important player in epidermal and tumour development. Klin Onkol 2012;25(Suppl2):2S11 2S Pastorek, M., Müller, P., Vojtěšek, B. Nrf2 dve tváre regulátora antioxidačného systému. Klin Onkol 2015;28(Suppl 2):2S26 2S Petrová M., Laco J., Červíček K., Tomšová M. Tubulo-skvamózní polyp vaginy. Ceska Gynekol 2015;80(3): (bez IF) 29. Pilatova, K., Mrkvicova, M., Zdrazilova-Dubska, L., Obermannova, R., Valik, D. Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients. Folia Mendeliana 2013;49(2): Procházková, I., Vojtěšek, B. Polo-like kináza 1 jako cíl protinádorové terapie. Klin Onkol 2015;28(Suppl 2):2S32 2S Ryška A., Hovorková E., Torgersen F., Rozkoš, T., Laco, J., Hornychová, H. Hopes and pitfalls of the molecular classification of breast cancer. Cesk Patol 2015;51(1): (bez IF) 32. Springer, D., Valík, D., Topolčan, O., Nekulová, M., Zdražilová Dubská, L., Malbohan, I., 10 z 55

11 Fuchsová, R., Svobodová, Š., Zima, T. Nádorové markery v klinické praxi. Postgraduální medicína 2013;15(příloha č.3): Šachlová, M. Malnutrice pacientů s karcinomem žaludku a nutriční podpora. Onkologická Revue 2015;září 2015: ISBN Špaček, J., Laco, J., Petera, J., Sedláková, I., Řezáč, A. Lze považovat i na začátku třetího tisíciletí primární karcinom vejcovodu za enigma? Čes Gynek 2013;78(6): Torgensen F., Dušek L., Matějková A., Rozkoš T., Laco J., Ryška A. EGFR in triple negative breast carcinoma: significance of protein expression and high gene copy number. Cesk Patol 2015;51(2): (bez IF) 36. Zahradníková, M., Vojtěšek, B., Hernychová, L. Cukry zasahují aneb glykomika na poli nádorových biomarkerů. Klin Onkol 2015;28(Suppl 2):2S20 2S25. BBMRI project supported the special issue of Klinicka Onkologie journal - Klin Onkol 2014; 27 (Suppl 1) - dealing with methods in applied molecular oncology used in RECAMO research centre. c) Chapter in a book 1. Valík, D., Zdražilová Dubská, L. Klinické využití solubilních nádorových marekrů. In: Tomášek, J. a kol.: Onkologie - minimum pro praxi. 1. vyd. Praha; Axonite CZ 2015, ISBN , s d) Certified methodology 1. Mrkvicová, M., Valík, D., Zdražilová Dubská L. Stanovení mutací v genu TPMT: detekce na základě mutačně specifické real-time PCR N/A - Uplatněná certifikovaná metodika. RIV/ : /14:# e) Graduate theses 1. Diploma thesis: Mgr. Edita Zemanová: Implementace farmakogenetického a farmakokinetického vyšetření k predikci toxicity spojené s podáním fluoropyrimidinů do klinické praxe. Vysoká škola zdravotníctva a sociálnej práce sv. Alžbety v Bratislave; Ústav zdravotníckych disciplín, Školitel: Mgr. Martina Mrkvicová, Ph.D. Počet stran: 76. 2) Results utilizing the infrastructure without LM dedication a) Publications in journals with impact factor (J imp ) 1. Adamcová, M., Lenčová, O., Jirkovský, E., Mazurová, Y., Palička, V., Šimko, F., Geršl, V., Štěrba, M. Experimental determination of diagnostic window of cardiac troponins in the development of chronic anthracycline cardiotoxicity and estimation of its predictive value. International Journal of Cardiology 2015;201: (IF= 4.036) 2. Adamkov J., Kašparová P., Česák T.: Inflammatory pseudotumor imitating intracranial meningioma a case report. Cesk Slov Neurol N 2015;78(111, 2): (IF = 0,165) 3. Alemany, L., Saunier, M., Alvarado-Cabrero, I., Quirós, B., Salmeron, J., Shin, H.-R., Pirog, E. C., Guimerà, N., Hernandez-Suarez, G., Felix, A., Clavero, O., Lloveras, B., Kasamatsu, E., Goodman, M.T., Hernandez, B.Y., Laco, J., Tinoco, L., Geraets, D.T., Lynch, C.F., Mandys, V., Poljak, M., Jach, R., Verge, J., Clavel, C., Ndiaye, C., Klaustermeier, J., Cubilla, A., Castellsagué, X., Bravo, I.G., Pawlita, M., Quint, W.G., Muñoz, N., Bosch, F.X., de Sanjosé, 11 z 55

12 S.; HPV VVAP Study Group: Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide. Int J Cancer 2015;136(1): (IF = 5,007) 4. ANDRÝS, Ctirad - KACEROVSKÝ, Marian - DRAHOŠOVÁ, Marcela - MUSILOVÁ, Ivana - PLÍŠKOVÁ, Lenka - HORNYCHOVÁ, Helena - PROCHÁZKA, Martin - JACOBSSON, Bo. Amniotic fluid soluble Toll-like receptor 2 in pregnancies complicated by preterm prelabor rupture of membranes. Journal of Maternal-Fetal and Neonatal Medicine, 2013, 26(5), ISSN IF ARAKELYAN, A., R. ZAKHARYAN, M. HAMBARDZUMYAN, J. PETRKOVA, M.CH. OLSSON, M. PETREK a A. BOYAJYAN. Functional genetic polymorphisms of monocyte chemoattractant protein 1 and C-C chemokine receptor type 2 in ischemic stroke. Journal of Interferon and Cytokine Research. 2014, 34(2), ISSN IF (2013): BALÍK, Martin - ZAKHARCHENKO, Mykhaylo - LEDEN, Pavel - OTÁHAL, Michal - HRUBÝ, Jan - POLÁK, Ferdinand - RUSINOVÁ, Kateřina - STACH, Zdeněk - TOKARIK, Monika - VÁVROVÁ, Jaroslava - JABOR, Antonín - OUDEMANS-VAN STRAATEN, Heleen M. Bioenergetic gain of citrate anticoagulated continuous hemodiafiltration-a comparison between 2 citrate modalities and unfractionated heparin. Journal of Critical Care, 2013, 28(1), ISSN IF BALÍK, Martin - ZAKHARCHENKO, Mykhaylo - OTÁHAL, Michal - HRUBÝ, Jan - POLÁK, Ferdinand - RUSINOVÁ, Kateřina - STACH, Zdeněk - VÁVROVÁ, Jaroslava - JABOR, Antonín. Quantification of Systemic Delivery of Substrates for Intermediate Metabolism during Citrate Anticoagulation of Continuous Renal Replacement Therapy. Blood Purification, 2012, 33(1-3), ISSN IF BALIK, V., J. SROVNAL, I. SULLA, O. KALITA, T. FOLTANOVA, M. VAVERKA, L. HRABALEK a M. HAJDÚCH. MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. Journal of Neuro-Oncology. 2013, 112(1), 1-8. ISSN X. IF (2012): BALIK, V., R. TROJANEC, M. HOLZEROVA, L. TUCKOVA, I. SULLA, M. MEGOVA, M. VAVERKA, L. HRABÁLEK a J. EHRMANN. An adult multifocal medulloblastoma with diffuse acute postoperative cerebellar swelling: immunohistochemical and molecular genetics analysis. Neurosurg Rev Jan;38(1):1-10. ISSN IF (2013): BERÁNEK, Martin - DRASTÍKOVÁ, Monika - BUCHTA, Vladimír - KESTŘÁNEK, Jan - ŠPAČEK, Jiří - PETERA, Jiří. Jednosměrné sekvenování PCR produktů MBL2 genu pomocí polyadenylovaného sekvenačního primeru. Chemické listy, 2012, 106(8), ISSN IF BERÁNEK, Martin - DRASTÍKOVÁ, Monika - PETERA, Jiří. Multiplexní dideoxynukleotidové sekvenování s polyadenylovanými sekvenačními primery. Chemické listy, 2013, 107(1), ISSN IF BERÁNEK, Martin - DRASTÍKOVÁ, Monika - SIRÁK, Igor - PAULÍKOVÁ, Simona - VOŠMIK, Milan - PETERA, Jiří. Využití jednokapilárového obousměrného sekvenování pro genotypizaci TGFβ1 genu. Chemické listy, 2013, 107(11), ISSN IF Beránek, M., Drastíková, M., Bureš, J., Palička, V. Preparing Triple-Compound Heterozygous Control Material for Molecular Diagnostics of TPMT Allelic Variants. Folia Biologica 2015;61(3): (IF= 1.000) 14. Beránek, M., Drastíková, M., Gabalec, F., Palička, V., Čáp, J. Syntetický multilokusový kalibrátor pro studium genové exprese v nádorech hypofýzy vyvolávajících akromegalii. 12 z 55

13 Chemické listy, 2015;109(12): (IF= 0.272) 15. Besik, J., Pirk, J., Netuka, I., Szarszoi, O., Marek, T., Urban, M., Honsová, E., Laco, J.: Aortic and mitral valve replacement due to extensive inflammatory immunoglobulin G4-related pseudotumor. Ann Thorac Surg 2015;100(4): (IF = 3,849) 16. Besse, L., Sedlaříková, L., Kryukov, F., Nekvindová, J., Radová, L., Slabý, O., Kuglík, P., Almasi, M., Penka, M., Krejčí, M., Adam, Z., Pour, L., Ševčíková, S., Hájek, R. Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma. PLoS ONE 2015;10(9):Art No. e (IF= 3.234) 17. BIENERTOVÁ-VAŠKŮ, Julie - MAZÁNEK, Pavel - HÉŽOVÁ, Renata - ČURDOVÁ, Anna - NEKVINDOVÁ, Jana - KŘEN, Leoš - ŠTĚRBA, Jaroslav - SLABÝ, Ondřej. Extension of microrna expression pattern associated with high-risk neuroblastoma. Tumor Biology, 2013, 34(4), ISSN IF BOLEHOVSKÁ, Radka - POSPÍŠILOVÁ, Monika - RYCHTRMOC, David - HUBÁLKOVÁ, Lenka - ČERVINKOVÁ, Zuzana. Induction of uncoupling protein-2 mrna by triiodothyronine in rat liver. Acta Veterinaria Brno, 2012, 81(1), ISSN IF BUREŠ, Jan - ŠMAJS, David - KVĚTINA, Jaroslav - FÖRSTL, Miroslav - ŠMARDA, Jan - KOHOUTOVÁ, Darina - KUNEŠ, Martin - CYRANY, Jiří - TACHECÍ, Ilja - REJCHRT, Stanislav - LESNÁ, Jiřina - VOŘÍŠEK, Viktor - KOPÁČOVÁ, Marcela. Bacteriocinogeny in experimental pigs treated with indomethacin and Escherichia coli Nissle. World Journal of Gastroenterology, 2011, 17(5), ISSN IF BUREŠ, Jan - KOPÁČOVÁ, Marcela - KOUPIL, Ilona - SEIFERT, Bohumil - ŠKODOVÁ FENDRICHOVÁ, Miluška - ŠPIRKOVÁ, Jana - VOŘÍŠEK, Viktor - REJCHRT, Stanislav - DOUDA, Tomáš - KRÁL, Norbert - TACHECÍ, Ilja. Significant decrease in prevalence of Helicobacter pylori in the Czech Republic. World Journal of Gastroenterology, 2012, 18(32), ISSN IF Cecka F, Ferko A, Jon B, Subrt Z, Kasparova P, Repak R. Pancreatic Castleman disease treated with laparoscopic distal pancreatectomy. Hepatobiliary Pancreat Dis Int Jun;12(3): IF2012: CERAL, Jiří - HABRDOVÁ, Vilma - VOŘÍŠEK, Viktor - BÍMA, Marcel - PELOUCH, Radek - SOLAŘ, Miroslav. Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy. Hypertension Research, 2011, 34(1), ISSN IF CIZKOVA, M., A. SUSINI, S. VACHER, G. CIZERON-CLAIRAC, C. ANDRIEU, K. DRIOUCH, E. FOURME, R. LIDEREAU a I. BIÉCHE. PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups. Breast Cancer Research. 2012, 14(1), Article Number: R28. ISSN X. IF (2011): CIZKOVA, M., M.E. DUJARIC, J. LEHMANN-CHE, V. SCOTT, O. TEMBO, B. ASSELAIN, J.Y. PIERGA, M. MARTY, CREMOUX, P. DE, F. SPYRATOS a I. BIÉCHE. Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab. British Journal of Cancer. 2013, 108(9), ISSN IF (2012): CIZKOVA, M., S. VACHER, D. MESEURE, M. TRASSARD, A. SUSINI, D. MLCUCHOVA, C. CALLENS, E. ROULEAU, F. SPYRATOS, R. LIDEREAU a I. BIÉCHE. PIK3R1 underexpression is an independent prognostic marker in breast cancer. BMC Cancer. 2013, 13(1), ISSN IF (2012): Cobo T, Kacerovsky M, Andrys C, Drahosova M, Musilova I, Hornychova H, Jacobsson B. 13 z 55

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28 using Raman spectroscopy. Analyst. 2013, 138(20), ISSN IF (2012): REPTOVA, S., K.S. TRTKOVA a Z. KOLAR. Direct Detection of the AR-E211 G > A Gene Polymorphism from Blood and Tissue Samples Without DNA Isolation. Pathology & Oncology Research. 2014, 20(2), ISSN ISSN (2013): Rozkoš, T., Ryška, A., Čáp, J., Sobande, F., Laco, J.: Cellular cohesiveness in benign and malignant thyroid follicular tumours varies significantly, but the difference is not useful in diagnosis of individual cases. Cytopathology, 2012, 23(1): IF= Sedláková, I., Laco, J., Caltová, K., Červinka, M., Tošner, J., Řezáč, A., Špaček, J.: Clinical significance of the resistance proteins LRP, Pgp, MRP1, MRP3, and MRP5 in epithelial ovarian cancer. Int J Gynecol Cancer 2015;25(2): (IF = 1,949) 189. SEDLÁKOVÁ, Iva - VÁVROVÁ, Jaroslava - TOŠNER, Jindřich - HANOUSEK, Ladislav. Lysophosphatidic acid (LPA) - a perspective marker in ovarian cancer. Tumor Biology, 2011, 32(3), ISSN IF SEVCIK, J., M. FALK, L. MACUREK, P. KLEIBLOVA, F. LHOTA, J. HOJNY, L. STEFANCIKOVA, M. JANATOVA, J. BARTEK, J. STRIBRNA, Z. HODNY, L. JEZKOVA, P. POHLREICH a Z. KLEIBL. Expression of human BRCA1Δ17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response. Cellular Signalling. 2013, 25(5), ISSN IF (2012): Skalová, A., Altemani, A., Silvana Di Palma, Roderick HW Simpson, Hosticka, L., Andrle, P., Laco, L., Toner, M., Vozmitsel, MA., Szakacs, S., Kazakov, DV.,Kinkor, Z., Michal, M.: Pleomorphic Adenoma of the Salivary Glands With Intravascular Tumor Deposits A Diagnostic Pitfall. American Journal of Surgical Pathology, 2012, roč. 36, č. 11, s IF= Skálová, S., Minxová, L., Lukeš, A., Dědek, P., Toušovská, K., Podhola, M.: Renal Vein Thrombosis with Pulmonary Embolism: First Manifestation of Lupus Nephritis. Journal of Paediatrics and Child Health, 2011, roč. 47, č. 5, s IF2010: Skalova, A., Weinreb, I., Hyrcza, M., Simpson, R.H.W., Laco, J., Agaimy, A., Vazmitel, M., Majewska, H., Vanecek, T., Talarčik, P., Manajlovic, S., Losito, S.N., Šteiner, P., Klimkova, A., Michal, M.: Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol 2015;39(3): (IF = 4,592) 194. SKARDA, J., Z. KOLAR, M. JANÍKOVÁ, L. RADOVÁ, V. KOLEK, E. FRIDMAN a J. KOPOLOVIC. Analysis of the prognostic impact of nestin expression in non-small cell lung cancer. Biomedical Papers of the Medical Faculty of Palacký University, Olomouc, Czech Republic. 2012, 156(2), ISSN IF (2011): Skoloudik, L., Kalfert, D., Zborayova, K., Laco, J.: Autoclaving of the middle ear ossicles in an animal experimental model. Acta Otolaryngol., 2013, 133, 12, s IF = 1, SLOBODOVÁ, Z., J. EHRMANN, V. KREJČÍ, J. ZAPLETALOVÁ a B. MELICHAR. Analysis of CD40 expression in breast cancer and its relation to clinicopathological characteristic. Neoplasma. 2011, 58(3), ISSN IF (2010): SMILEK, P., J. NEUWIRTHOVÁ, J. JARKOVSKY, L. DUSEK, J. ROTTENBERG, R. KOSTŘICA, J. SROVNAL, M. HAJDÚCH, J. DRÁBEK a J. KLOZAR. Epidermal growth factor receptor (EGFR) expression and mutations in the EGFR signaling pathway in correlation 28 z 55

29 with anti-egfr therapy in head and neck squamous cell carcinomas. Neoplasma. 2012, 59(5), ISSN IF (2011): Sobande, F., Samayoa, Luis M., Moore, A. R., Adams, K., Reynolds, C.: Primary Pulmonary Synovial Sarcoma Presenting as a Breast Mass. Breast J, 2011, 17(4): IF2010: SOHN, J.J., A.J. SCHETTER, H.G. YFANTIS, L.A. RIDNOUR, I. HORIKAWA, M.A. KHAN, A.I. ROBLES, S.P. HUSSAIN, A. GOTO, E.D. BOWMAN, L.J. HOFSETH, J. BARTKOVA, J. BARTEK, J.G. WOGAN, D.A. WINK a C.C. HARRIS. Macrophages, nitric oxide and micrornas are associated with DNA damage response pathway and senescence in inflammatory bowel disease.plos One. 2012, 7(9), e ISSN IF(2011): Soukup, T., Doseděl, M., Nekvindová, J., Tomš, J., Vlček, J., Pávek, P. Genetic polymorphisms in metabolic pathways of leflunomide in the treatment of rheumatoid arthritis. Clinical and Experimental Rheumatology 2015;33(3): (IF= 2.724) 201. Soukup, T., Doseděl, M., Pávek, P., Nekvindová, J., Barvík, I., Bubancová, I., Bradna, P., Kuběna, A., Carazo Fernandez, A., Veleta, T., Vlček, J. The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients. Rheumatology International 2015;35(7): (IF= 1.516) 202. STAHELOVA, A. - PETRKOVA, J. - MOTAKOVA, N. - TABORSKY, M. MRAZEK, F. PETREK, M.. The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients. Cytokine. 2011, 53(1), ISSN IF (2010): STAHELOVA, A., J. PETRKOVA, M. PETREK a F. MRAZEK. Sequence variation in promoter regions of genes for CC chemokine ligands (CCL)19 and 21 in Czech patients with myocardial infarction. Molecular Biology Reports. 2014, 41(5), ISSN IF (2013): STRANSKA, J., JANCIK, S., SLAVKOVSKY, R., HOLINKOVA, V., RABCANOVA, M., VOJTA, P., HAJDUCH, M. a DRABEK, J. Whole genome amplification induced bias in the detection of KRAS-mutated cell populations during colorectal carcinoma tissue testing. Electrophoresis: an international journal, 2015, 36(6), , IF = 3, STRAUSS, R., Z.Y. LI, Y. LIU, I. BEYER, J. PERSSON, P. SOVA, T. MÖLLER, S. PESONEN, A. HEMMINKI, P. HAMERLIK, C. DRESCHER, N. URBAN, J. BARTEK a A. LIEBER. Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity. Plos One. 2011, 6(1), e ISSN IF (2010): STROJNÝ, L., J. ŠTOFILOVÁ, E. HIJOVÁ, V. SZABADOSOVÁ, R. SALAJ, I. BERTKOVÁ, A. CHMELÁROVÁ, D. ČOKÁŠOVÁ, B. PRAMUKOVÁ, A. BRANDEBUROVÁ, A. BOMBA, N. BOBROV a P. SUCHÁNEK. Effect of Lactobacillus plantarum LS/07 in combination with flaxseed oil on the microflora, enzymatic activity, and histological changes in the development of chemically induced precancerous growth in the rat colon. Czech Journal of Animal Science. 2014, 59(6), ISSN IF (2013): SURINOVA, S., M. CHOI, S. TAO, P.J. SCHÜFFLER, C.Y.. CHANG, T. CLOUGH, K. VYSLOUŽIL, M. KHOYLOU, J. SROVNAL, Y. LIU, M. MATONDO, R. HÜTTENHAIN, H. WEISSER, J.M. BUHMANN, M. HAJDÚCH, H. BRENNER, O. VITEK a R. AEBERSOLD. Prediction of colorectal cancer diagnosis based on circulating plasma proteins. EMBO Molecular Medicine. 2015, 7(9), ISSN IF (2014): SURINOVA, S., L. RADOVÁ, M. CHOI, J. SROVNAL, H. BRENNER, O. VITEK, M. HAJDÚCH a R. AEBERSOLD. Non-invasive prognostic protein biomarker signatures associated with colorectal cancer. EMBO Molecular Medicine. 2015,7(9), ISSN 29 z 55

30 IF (2014): SVOBODA, M., J. SANA, P. FABIAN, I. KOCÁKOVÁ, J. GOMBOSOVA, J. NEKVINDOVÁ, L. RADOVÁ, R. VYZULA a O. SLABY. MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients. Radiation Oncology. 2012, 7(-), Article Number: 195. ISSN X. IF (2011): Školoudík, L., Vokurka, J., Šimáková, E.: Mechanical treatment and autoclaving of middle ear ossicles from cholesteatomatous ears. Central European Journal of Medicine, 2012, roč. 7, č. 2, s IF= Šteiner, I., Krbal, L., Rozkoš, T., Harrer, J., Laco, J.: Calcific aortic stenosis: immunohistochemical analysis of inflammatory infiltrate. Pathology - Research and Practice, 2012, roč. 208, č. 4, s IF2011: Šteiner, I., Laco, J.: IgG4-related disease of the aortic valve. Cardiovasc Pathol 2015;24(4):264. (IF = 2,336) 213. ŠTĚPÁNOVÁ, Vlasta - PLÍŠKOVÁ, Lenka - KUBIŠOVÁ, Michaela - ŠTĚPÁNOVÁ, Eva - BOLEHOVSKÁ, Radka - BOŠTÍKOVÁ, V. - SVOBODOVÁ, Michaela. Využití testů avidity IgG protilátek v diagnostice cytomegalovirové infekce. Epidemiologie, mikrobiologie, imunologie, 2011, 60(3), ISSN IF Tambor, V., Kacerovský, M., Andrýs, C., Musilová, I., Hornychová, H., Plíšková, L., Link, M., Stulík, J., Lenčo, J.: Amniotic Fluid Cathelicidin in PPROM Pregnancies: From Proteomic Discovery to Assessing Its Potential in Inflammatory Complications Diagnosis. PLoS ONE, 2012, roč. 7, č. 7, nestránkována. IF= TERESHCHENKO, I.P., J. PETRKOVA, M.I. VOEVODA, M. TABORSKY, Z. NAVRATILOVA, A.N. ROMASCHENKO, V.N. MAKSIMOV, F. MRAZEK a M. PETREK. CCL5/RANTES gene polymorphisms in Slavonic patients with myocardial infarction. Mediators of Inflammation. 2011, 2011(article ), 1-6. ISSN IF (2010): Tsiartas P, Kacerovsky M, Musilova I, Hornychova H, Cobo T, Sävman K, Jacobsson B. The association between histological chorioamnionitis, funisitis and neonatal outcome in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med Sep;26(13): IF2012: TOMŠÍK, Pavel - MIČUDA, Stanislav - SUCHÁ, Lenka - ČERMÁKOVÁ, Eva - ŠUBA, Petr - ŽIVNÝ, Pavel - MAZUROVÁ, Yvona - KNÍŽEK, Jiří - NIANG, Mohamed - ŘEZÁČOVÁ, Martina. The anticancer activity of alpha-tomatine against mammary adenocarcinoma in mice. Biomedical Papers, 2013, 157(2), ISSN IF VAŠATOVÁ, Martina - PUDIL, Radek - HORÁČEK, Jan - BÜCHLER, Tomáš. Current Applications of Cardiac Troponin T for the Diagnosis of Myocardial Damage. Advances in Clinical Chemistry, 2013, 61(neuvedeno), ISSN IF VAŠATOVÁ, Martina - PUDIL, Radek - ŠAFKA, Václav - FEJFAR, Tomáš - BÜCHLER, Tomáš - HŮLEK, Petr - PALIČKA, Vladimír. Elevated cardiac markers are associated with higher mortality in patients after transjugular intrahepatic portosystemic shunt insertion. Annals of Clinical Biochemistry, 2013, 50(2), ISSN IF VAŠATOVÁ, Martina - PUDIL, Radek - TICHÝ, Miloš - BÜCHLER, Tomáš - HORÁČEK, Jan - HAMAN, Luděk - PAŘÍZEK, Petr - PALIČKA, Vladimír. High-sensitivity troponin T as a marker of myocardial injury after radiofrequency catheter ablation. Annals of Clinical Biochemistry, 2011, 48(Pt. 1), ISSN IF VÁVROVÁ, Jaroslava - MAISNAR, Vladimír - TICHÝ, Miloš - FRIEDECKÝ, Bedřich - 30 z 55

31 ČERMÁKOVÁ, Zdeňka - DASTYCH, Milan - GOTTWALDOVÁ, Jana - KUČERA, Petr - KROTKÁ, Jarmila - RACEK, Jaroslav - ŽENKOVÁ, Jana - SCHNEIDERKA, Petr - LOCHMAN, Pavel - ZIMA, Tomáš - BENÁKOVÁ, Hana - BÜCHLER, Tomáš - SPÁČILOVÁ, Jana - HÁJEK, Roman - PALIČKA, Vladimír. Interlaboratory study of free monoclonal immunoglobulin light chain quantification. Clinical Chemistry and Laboratory Medicine, 2011, 49(1), ISSN IF ) 222. Vejražková, E., Hubáček, P., Kutová, R., Plíšková, L., Košťál, M., Štěpánová, V., ZAVŘELOVÁ, A., Radocha, J., Malá, E., Žák, P. Klinická rezistence lidského cytomegaloviru při léčbě gancyklovirem u pacientů po alogenní transplantaci hematopoetických buněk - zkušenosti jednoho centra. Epidemiol Mikrobiol Imunol 2015;64(3): (IF= 0.353) 223. Vosmik, M., Sirak, I., Dvorak, J., Lesko, M., Repak, R., Kopacova, M., Hodek, M., Laco, J., Melichar, B., Petera, J.: Effect of Preoperative Chemoradiation in Clinically Resectable Gastroesophageal Cancer: Single Institution Experience. Int. J. Radiat. Oncol. Biol. Phys., 2011, roč. 81, č. 2 (Suppl. S), s. S329-S329. IF = 4, Vosmik, M., Laco, J., Sirak, I., Lesko, M., Repak, R., Dvorak, J., Melichar, B., Lochman, P., Hodek, M., Petera, J.: Long-term results of preoperative chemoradiation in clinically resectable gastroesophageal cancer: A single institution experience. Eur J Cancer 2015;51(Suppl. 3):S412-S413. (IF = 5,417) 225. VRÁNOVÁ, J., M. HENDRICHOVA, H. KOLÁŘOVÁ, K. KRATKA, J. ROSINA a J. HORAK. 13C-methacetin breath test in the evaluation of disease severity in patients with liver cirrhosis. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2013, 157(4), ISSN IF (2012): VRZALIKOVA, K., C.B.J. WOODMAN a P.G. MURRAY. BLIMP1 alpha, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2012, 156(1), 1-6. ISSN IF (2011): Vytřísalová, M., Toušková, T., Ládová, K., Fuksa, L., Palička, V., Matoulková, P., Horák, P., Štěpán, J. Adherence to oral bisphosphonates: 30 more minutes in dosing instructions matter. Climacteric 2015;18(4): (IF= 2.264) 228. ZADRAŽIL, J., P. HORÁK, P. ŠTREBL, K. KREJČÍ, M. KAJABOVÁ, P. SCHNEIDERKA, J. ZAPLETALOVÁ, A. GALANDÁKOVÁ, J. VOSTÁLOVÁ a H. VAVERKOVÁ. In vivo oxidized lowdensity lipoprotein (ox-ldl) aopp and tas after kidney transplantation: a prospective, randomized one year study comparing cyclosporine A and tacrolimus based regiments. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2012, 156(1), ISSN IF (2011): ZAKHARYAN, R., A. BOYAJYAN, A. ARAKELYAN, A. GEVORGYAN, F. MRAZEK a M. PETREK. Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population. Human Immunology. 2011, 72(9), ISSN IF (2010): ZAKHARYAN, R., A. BOYAJYAN, A. ARAKELYAN, M. MELKUMOVA, F. MRAZEK a M. PETREK. Monocyte chemoattractant protein-1 in schizophrenia: -2518A/G genetic variant and protein levels in Armenian population. Cytokine. 2012, 58(3), ISSN IF (2011): ZATLOUKALOVÁ, Libuše - FILIPSKÝ, Tomáš - MLADĚNKA, Přemysl - SEMECKÝ, Vladimír - MACÁKOVÁ, Kateřina - HOLEČKOVÁ, Magdalena - VÁVROVÁ, Jaroslava - PALIČKA, Vladimír - HRDINA, Radomír. Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity. Canadian Journal of Physiology and 31 z 55

32 Pharmacology, 2012, 90(4), ISSN IF ŽĎÁROVÁ KARASOVÁ, Jana - ZEMEK, Filip - BAJGAR, Jiří - VAŠATOVÁ, Martina - PROCHÁZKA, Petr - NOVOTNÝ, Ladislav - KUČA, Kamil. Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain. Journal of Pharmaceutical and Biomedical Analysis, 2011, 54(5), ISSN IF b) Publications in reviewed journals without impact factor (J rec ) 1. Atanasová, L., Laco, J., Tuček, L., Slezák, R.: Pyogenní granulom v dokumentaci Stomatologické kliniky v Hradci Králové. LKS (Suplement), 2013, 15, 9, s. K Beránek, M. Aktuálně poptávané analyty v Registru raritních vyšetření. FONS 2015;23(4): BERÁNEK, Martin - DRASTÍKOVÁ, Monika - PAULÍKOVÁ, Simona - SIRÁK, Igor - VOŠMIK, Milan - PETERA, Jiří. Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma. Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Kralove, 2011, 54(3), ISSN BERÁNEK, Martin - DRASTÍKOVÁ, Monika - PETERA, Jiří. Polyadenylated Sequencing Primers Enable Complete Readability of PCR Amplicons Analyzed by Dideoxynucleotide Sequencing. Acta Medica (Hradec Králové), 2012, 55(4), ISSN BERÁNEK, Martin - HEGEROVÁ, Jaroslava - DRASTÍKOVÁ, Monika. "Alternativní" biologický materiál pro rutinní analýzu nukleových kyselin - validace preanalytické fáze vyšetření DNA. Klinická biochemie a metabolismus, 2012, 20(1), ISSN BERÁNEK, Martin - ŠTERN, Petr. Registr raritních vyšetření. Fons: informační bulletin, 2011, 21(3), ISSN BERÁNEK, Martin. Informace o aktuálním stavu Registru raritních vyšetření. FONS, 2013, 23(3), ISSN BLAŽKOVÁ, Šárka - VYTŘÍSALOVÁ, Magda - ŠTĚPÁN, Jan - PALIČKA, Vladimír - BÝMA, Svatopluk - HÁLA, Tomáš - VLČEK, Jiří. Secondary prevention of osteoporosis among general practitioners. Osteologický bulletin, 2012, 17(1), ISSN Bradna, P., Soukup, T., Tomš, J., Tošovský, M., Hrnčíř, Zb., Laco, J.: Aortitis a periaortitis v rámci IgG4 related choroby. Obtížná diagnóza s dobrou šancí léčby. Čes. Revmatol., 2013, 21, 1, s BUNEŠOVÁ, Martina - BLAŽKOVÁ, Jana - COUFAL, Petr - FRIEDECKÝ, Bedřich - KAPUSTOVÁ, Miloslava - KOTRBATÝ, Jiří - MALINA, Pavel. Doporučení k převzetí biologického materiálu klinickou laboratoří. Klinická biochemie a metabolismus, 2011, 19(2), ISSN Čelakovský, P., Kalfeřt, D., Smatanová, K., Chrobok, V., Laco, J. Detection of cervical lymph node micrometastases in patients with squamous cell carcinoma of the oral cavity, pharynx and larynx. Acta Medica (Hradec Kralove) 2015;58(2): Daum, O., Skálová, A., Rozkoš, T., Laco, J.: Prediktivní diagnostika HER2 v adenokarcinomu žaludku. Česko-slovenská patologie a Soudní lékařství, 2011, roč. 56, č. 4, s Dobiášová, P., Kokštein, Z., Koudelka, J., Podhola, M.: Spontánní intestinální perforace u nedonošených novorozenců. Neonatologické listy, 2012, roč. 18, č. 1, s DOUBKOVÁ, Kristýna - GRADOŠOVÁ, Iveta - ŠVEJKOVSKÁ, Klára - ŽIVNÝ, Pavel - ŽIVNÁ, 32 z 55

33 Helena - ČERMÁKOVÁ, Eva - PALIČKA, Vladimír. Vliv jaterní regenerace na metabolismus kostí dospělých samců kmene Wistar. Osteologický bulletin, 2013, 18(2), ISSN DRASTÍKOVÁ, Monika - BERÁNEK, Martin - HEGEROVÁ, Jaroslava - PUTZOVÁ, Daniela. Význam DNA vyšetření mutací C282Y, H63D a S65C v HFE genu. Časopis lékařů českých, 2012, 151(9), ISSN DRASTÍKOVÁ, Monika - GABALEC, Filip - ČÁP, Jan - BERÁNEK, Martin. Molecular biology investigation of somatostatin and estrogen receptors in clinically non-functioning pituitary adenomas. Klinická biochemie a metabolismus, 2013, 21(3), ISSN DULÍČEK, Petr - IVANOVÁ, Eva - SADÍLEK, Petr - BERÁNEK, Martin. Riziko trombózy při užívání hormonální antikoncepce z pohledu hematologa. Praktická gynekologie, 2013, 17(4), ISSN DULÍČEK, Petr - MALÝ, Jaroslav - PECKA, Miroslav - SADÍLEK, Petr - BERÁNEK, Martin. Kontraceptiva a tromboembolické příhody u adolescentek. Tempus medicorum, 2012, 21(1, (MF medireport)), ISSN DULÍČEK, Petr - SADÍLEK, Petr - BERÁNEK, Martin - PECKA, Miroslav. Výskyt venózního tromboembolismu u žen v časové souvislosti s užíváním hormonální antikoncepce. Transfuze a hematologie dnes, 2013, 19(1), ISSN Dušek, J., Matějková, A., Bednářová, J., Šteiner, I. (editor): Case : Cardiac amyloidosis. Acta medica, 2011, roč. 54, č. 2, s DUŠEK, Jaroslav - ŠŤÁSEK, Josef - BIS, Josef - BRTKO, Miroslav - VOJÁČEK, Jan - POLANSKÝ, Pavel - VAŠATOVÁ, Martina - ČERNOHORSKÝ, Dušan. Směřují markery myokardiální ischemie do klinické praxe? Intervenční a akutní kardiologie, 2012, 11(3-4), ISSN X. 22. Dvořák, J., Büchler, T., Filipová, A., Hadži Nikolov, D., Buka, D., Richter, I., Honzírková, M., Abrahámová, J. Primární řasinky v onkologii. Postgrad Med 2015;17(2): Dvořák, J., Dvořák, Z., Sitorová, V., Hadži Nikolov, D., Mokrý, J., Richter, I., Filip, S., Ryška, A., Petera, J.: Primární řasinky buněk pojivové tkáně. Česká revmatologie, 2012, roč. 20, č. 4, s Dvořák, J., Sitorová, V., Hadži N. D., Mokrý, J., Richter, I., Filip, S., Ryška, A., Petera, J.: Primární řasinky buněk kardiovaskulárního aparátu. Vnitřní lékařství, 2012, roč. 58, č. 12, s Dvořák, J., Sitorová, V., Hadži Nikolov, D., Mokrá, J., Richter, I., Filip, S., Ryška, A., Petera, J.: Primární řasinky a jejich biologické fukce. Onkologie, 2011, roč. 5, č. 4, s Dvořák, J., Sitorová, V., Hadži Nikolov, D., Mokrý, J., Richter, I., Kasaová, L., Filip, S., Ryška, A., Petera, J.: Primary cilium antenna-like structure on the surface of most mammalian cell types. Journal of Physics: Conference Series, 2011, roč. 329, FRIEDECKÝ, Bedřich - HOLEČKOVÁ, Magdalena. Kompenzace Jaffého metody stanovení kreatininu. FONS, 2012, 22(2), ISSN FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef - ŠPIRKOVÁ, Jana - BUDINA, Marek - PALIČKA, Vladimír. Studie čtyř systémů měření glykovaného hemoglobinu HbA1c v režimu POCT. Praktický lékař, 2011, 91(8), ISSN FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef. Diagnostické rozhodovací limity kardiálních troponinů v roce FONS, 2012, 22(3), ISSN z 55

34 30. FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef. Doporučení KDIGO Základní analyty a jejich analytické vlastnosti a problémy. FONS, 2013, 23(4), ISSN FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef. Glukometry a sledování pacientů v kritickém stavu. FONS, 2013, 23(1), ISSN FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef. Nové generace hs kardiálních troponinů a diagnóza akutního koronárního syndromu - minireview. Klinická biochemie a metabolismus, 2013, 21(4), ISSN FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef. Podněty a vybrané parametry k aktualizaci doporučení o laboratorní diagnostice diabetu, sledování jeho terapie. Současný stav. FONS, 2013, 23(1), ISSN FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef. SKUP - cesta ke zvýšení kvality péče o pacienty. Praktický lékař, 2012, 92(10-12), ISSN FRIEDECKÝ, Bedřich - KRATOCHVÍLA, Josef. Současné hodnoty (2012) 99 percentilů kardiálních troponinů. FONS, 2012, 22(4), ISSN FRIEDECKÝ, Bedřich - VÁVROVÁ, Jaroslava. Současný stav stanovení vitaminu D v séru. Klinická biochemie a metabolismus, 2012, 20(3), ISSN FRIEDECKÝ, Bedřich - VÁVROVÁ, Jaroslava. Stanovení 25-hydroxyvitaminu D v séru/plazmě - minireview. Klinická biochemie a metabolismus, 2011, 19(3), ISSN FRIEDECKÝ, Bedřich - VÁVROVÁ, Jaroslava. Zpráva o srovnatelnosti, standardizaci a hodnocení výsledků vitamínu D. FONS, 2012, 22(1), ISSN FRIEDECKÝ, Bedřich - ZIMA, Tomáš - KRATOCHVÍLA, Josef - SPRINGER, Drahomíra. Diabetes mellitus - laboratorní diagnostika a sledování stavu pacientů. Klinická biochemie a metabolismus, 2012, 20(2), ISSN FRIEDECKÝ, Bedřich. Analytická kvalita, nejistota měření a biologické variace. Klinická biochemie a metabolismus, 2012, 20(1), 3-4. ISSN FRIEDECKÝ, Bedřich. Glukometry v rukou pacientů, praktických lékařů a na jednotkách intenzívní péče. Praktický lékař, 2011, 91(10), ISSN FRIEDECKÝ, Bedřich. Kontrola kvality a management rizika. FONS, 2012, 22(1), ISSN FRIEDECKÝ, Bedřich. Kvalita měření glukózy v krvi osobními a POCT glukometry. Klinická biochemie a metabolismus, 2012, 20(3), ISSN FRIEDECKÝ, Bedřich. Matricové vlivy u laboratorních vzorků. Klinická biochemie a metabolismus, 2011, 19(1), 3-4. ISSN FRIEDECKÝ, Bedřich. Metrologie, akreditace a ISO Kde, jaké a jak nalézt poznatky o referenčních materiálech, referenčních metodách a návaznosti kalibrací. FONS, 2013, 23(3), ISSN FRIEDECKÝ, Bedřich. Parathyroidní hormon PTH. Klíčové informace pro potřeby externího hodnocení kvality. FONS, 2013, 23(2), ISSN GERLICHOVÁ, Monika - ŽIVNÝ, Pavel - MATĚJOVIČ, Martin - ČERNÝ, Vladimír. Nové biomarkery v diagnostice poruch renálních funkcí. Anesteziologie a intenzivni medicina, 2011, 22(1), ISSN GERLICHOVÁ, Monika - ŽIVNÝ, Pavel - MATĚJOVIČ, Martin - ČERNÝ, Vladimír. Klasifikace a diagnostika renálního poškození - stále nedokonalá?. Anesteziologie a intenzivni medicina, 34 z 55

35 2011, 22(1), ISSN GRADOŠOVÁ, Iveta - ŠVEJKOVSKÁ, Klára - ŽIVNÁ, Helena - ŽIVNÝ, Pavel - ČERMÁKOVÁ, Eva - TICHÝ, Aleš - PALIČKA, Vladimír. Vliv metoprololu na kostní tkáň u dospělých samců potkanů kmene Wistar. Osteologický bulletin, 2011, 16(1), 3-7. ISSN GRADOŠOVÁ, Iveta - ŽIVNÁ, Helena - ŽIVNÝ, Pavel - HUBENÁ, Soňa - ŠVEJKOVSKÁ, Klára - PALIČKA, Vladimír. Vliv metoprololu na kostní metabolismus u samců potkanů kmene Wistar po provedené orchidektomii. Osteologický bulletin, 2011, 16(4), ISSN Hanousková, K., Matějková, A., Navrátilová, M., Matějek, T., Koudelka, J., Rejtar, P., Kokštein, Z., Malý, J. Segmentální dilatace střeva - prezentace souboru novorozenců se segmentální dilatací tenkého střeva a přehled literatury. Československá pediatrie 2015;70(3): Harris, K.M., Špaček, J., Bell, M.E., Parker, P.H., Lindsey, L.F., Baden, A.D., Vogelstein, J.T., Burns, R. A resource from 3D electron microscopy of hippocampal neuropil for user training and tool development. Sci Data 2015;2: HORÁČEK, Jan - KUPSA, Tomáš - VAŠATOVÁ, Martina - JEBAVÝ, Ladislav - ŽÁK, Pavel. Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology. Experimental Oncology, 2013, 35(3), ISSN Hrdinová Marie, Nedal Omran, Pavel Polanský, Jiří Veselý, Ivo Steiner, Zdeněk Bělobrádek, Zdeněk Šorm. Left atrial leiomyosarcoma: A rare couse of mitral valve stenosis. Cor et Vasa 55, 2013 e457 e Hrnčíř, Z., Laco, J., Drahošová, M.: Biomarker IgG4 u Mikuliczovy choroby. Rheumatologia, 55. Zjazd slovenských a českých reumatológov - súhrny, 2011, roč. 25, č. 3., s Hrnčíř, Z., Laco, J., Slezák, R., Rencová, E., Drahošová, M., Brtková, J.: Mikuliczova choroba s jednostranným exoftalmem onemocnění se vztahem k IgG4. Čes. Revmatol., 2011, roč. 19, č. 3, s Hrnčíř, Z., Laco, J.: Klinický význam nemoci spojené s imunoglobuliny IgG4. Časopis lékařů českých, 2011, č. 8, s Chmelařová, M., Ruszová, E., Laco, J., Dvořáková, E., Smetana, J., Hrochová, K., Palička, V. Monitoring of DNA methylation in ovarian cancer using microarrays. Klin Biochem Metab 2015;23(3): CHMELAŘOVÁ, Marcela - PALIČKA, Vladimír. How to analyze DNA methylation? Journal of Turgut Ozal Medical Center, 2013, 20(3), ISSN CHMELAŘOVÁ, Marcela - PALIČKA, Vladimír. Nejčastěji využívané metodiky k analýze DNA metylačních změn. Časopis lékařů českých, 2011, 150(8), ISSN Chrobok, V., Ježek, B., Šimáková, E., Černý, M.: Dehiscence stěny kanálu a výhřez lícního nervu kasuistiky. Česká a slovenská neurologie a neurochirurgie, 2011, roč. 74, č. 4, s Jiráčková, J., Tichá, A., Hyšpler, R., Svobodová, I., Musil, F., Bláha, V., Sobotka, L., Zadák, Z., Šmahelová, A. Metabolismus cholesterolu u obézních pacientů s diabetes mellitus 1. typu - vliv redukce hmotnosti. Klinická biochemie a metabolismus 2015;23(2): Kalfeřt, D., Jakoubková, S., Hadži N.D., Čelakovský, P., Ludvíková, M. Mnohočetný neurofibrom hrtanu. Otorinolaryngologie a foniatrie, 2011, roč. 60, r. 2, s z 55

36 64. Kalfeřt, D., Kašparová, P., Čelakovský, P. Extranodální NK/T buněčný lymfom nazálního typu neobvyklá příčina jednostranné nosní obstrukce. Otorinolaryngologie a foniatrie, 2012, roč. 61, č. 2, s Kalfeřt, D., Laco, J., Čelakovský, P., Vošmik, M., Chrobok, V. Význam stanovení exprese proteinu p16ink4a (p16) u dlaždicobuněčných karcinomů hlavy a krku. Čas. Lék. Čes., 2012, 151, 10, s Košťál, M., Žák, P., Vejražková, E., Cermanová, M., Bělohlávková, P., Zavřelová, A., Vrbacký, F., Rozkoš, T., Nová, M.: Case : a 57-year-old woman with post-transplant lymphoproliferative disorder after allogeneic stem cell transplantation for primary myelofibrosis. Acta Medica (Hradec Králové)/Universitas Carolina, Facultas Medica Hradec Kralove, 2012, roč. 55, č. 3, s KOTINGOVÁ, Lenka - VOŘÍŠEK, Viktor - BORSKÁ, Lenka - ČERMÁKOVÁ, Eva - FIALA, Zdeněk. Vliv rozpouštědla na dermální absorpci pyrenu in vitro. Hygiena: časopis pro ochranu a podporu zdraví, 2012, 57(2), ISSN KOTINGOVÁ, Lenka - VOŘÍŠEK, Viktor - ČERMÁKOVÁ, Eva - BORSKÁ, Lenka - FIALA, Zdeněk. Vliv koncetrace na transdermální absorpci pyrenu in vitro. Pracovní lékařství, 2012, 64(1), ISSN Králíčková, P., Slezák, R., Vošmik, M., Malá, P., Hornychová, H., Brožík, J., Melichar, B.: Goodův syndrom (s thymomem spojená hypogamaglobulinemie) 2 kazuistiky. Vnitřní lékařství, 2012, roč. 58, č. 2, s KŘEPINSKÁ, Eva - CHMELAŘOVÁ, Marcela - LACO, Jan - PALIČKA, Vladimír - ŠPAČEK, Jiří. Jaký je prognostický význam molekulárně genetických faktorů u karcinomu endometria?. Klinická onkologie, 2012, 25(4), ISSN X. 71. Kubišová, M., Šafránek, R., Ságová, M., Horáček, J., Podhola, M., Dusilová-Sulková, S.: Pokročilá sekundární hyperplarathyreóza při selhání ledvin chirurgická či farmakologická léčba? popis dvou případů. Osteologický bulletin, 2011, roč. 16, č. 1, s KUČEROVÁ, Petra - ČERMÁKOVÁ, Zuzana - PLÍŠKOVÁ, Lenka - VALENTA, Zbyněk - PAVLIŠ, Pavel - KUBÍČKOVÁ, P.. Porovnání výsledků dvou metod sérologické diagnostiky leptospirózy - mikroaglutinačního testu a metody ELISA. Klinická mikrobiologie a infekční lékařství, 2011, 17(5), ISSN X. 73. KULTAN, J., KOLEK, V., FAJKOSOVA, L., HAJDUCH, M., DRABEK, J., TICHY, T. a TACHEZY, R. Recurrent respiratory papillomatosis successfully treated with gefitinib: a case study. American Journal of Medical Case Reports, 2015, 3(11), Louda, M., Pacovský, J., Novák, I., Giblo, V., Hušek, P., Kutílek, P., Hurtová, M., Podhola, M., Páral, J., Broďák, M.: Histologická skladba metastáz do oblasti retroperitonea. Urologie pro praxi, 2012, roč. 13, č. 6, s Matějek, T., Navrátilová, M., Kokštějn, Z., Palička, V. Metabolické kostní onemocnění při nezralosti. Československá pediatrie 2015;70(5): Melichar B, Voboril Z, Krajina A, Malírová E, Weiner P, Nová M, Ryska A, Dvorák J. Hepatic arterial infusion of irinotecan, 5-Fluorouracil and leucovorin in patients with liver metastases from colorectal carcinoma. Anticancer Res Dec;32(12): IF2011: MICHAJLÍKOVÁ, Marta - HOLEČKOVÁ, Magdalena - BLAŽKOVÁ, Jana - FRIEDECKÝ, Bedřich. Sledování četnosti hemolytických sér v Ústavu klinické biochemie a diagnostiky Fakultní nemocnice Hradec Králové. Fons: informační bulletin, 2011, 21(4), ISSN z 55

37 78. Mitášová E, Kacerovský M, Krejsek J, Hornychová H, Andrýs C. Umbilical cord blood soluble Toll-like receptor 2 in pregnancies complicated by preterm premature rupture of membranes. Ceska Gynekol Aug;78(4): Czech. 79. Nováková, V., Belada, D., Laco, J., Kašparová, P., Nová, M., Slezák, R.: Maligní lymfomy nehodgkinova typu v dokumentaci Stomatologické kliniky v Hradci Králové Česká stomatologie, 2011, roč. 111, č. 2, s Nováková, V., Slezák, R., Laco, J., Tuček L., Ryška, A.: Dlaždicobuněnčný karcinom ústní sliznice a rtu v dokumentaci. Stomatologické kliniky LF UK a FN v Hradci Králové v letech Praktické zubní lékařství, 2012, roč. 60, č. 2, s ONDRYASOVA, H., KOUDELAKOVA, V., DRABEK, J., VANEK, P., SLAVKOVSKY, R. a HAJDUCH, M. Pilotní studie pro využití samoodběrové soupravy a molekulární diagnostiky HPV infekce pro skrínink karcinomu děložního čípku. Ceska Gynekologie, 2015, 80(6), Palička, V., Dusilová Sulková, S., Rychlík, P., Kasalický, P., Bubeníček, P. Diagnostika metabolických osteopatií - specifika v nefrologii. Osteologický bulletin 2015;20(2): PALIČKA, Vladimír. Doporučený postup pro sledování pacientů léčených deriváty parathormonu. Osteologický bulletin, 2013, 18(4), ISSN PALIČKA, Vladimír. Geny a osteoporóza - editorial. Vnitřní lékařství, 2011, 57(1), ISSN X. 85. PALIČKA, Vladimír. Kostní tkáň a hormony. Postgraduální medicína, 2013, 15(7), ISSN PALIČKA, Vladimír. Některé novinky v osteoporóze a metabolismu kostní tkáně. Medicína pro praxi, 2012, 9(11), ISSN PALIČKA, Vladimír. Osteoporóza u žen s poruchami výživy. Postgraduální medicína, 2013, 15(1), ISSN PALIČKA, Vladimír. Personalizovaná medicína a její (možné) postavení v kardiologii. Intervenční a akutní kardiologie, 2012, 11(1), 6-8. ISSN X. 89. PALIČKA, Vladimír. Postmenopauzální osteoporóza. Acta medicinae, 2013, 2(6 (Praktický lékař)), ISSN X. 90. PALIČKA, Vladimír. Vitamin D a jeho role (nejen) v osteologii. Interní medicína pro praxi, 2011, 13(10), ISSN PALIČKA, Vladimír. Vitamin D: skeletální a extraskeletální účinky. Medicína pro praxi, 2013, 10(5), ISSN PALIČKA, Vladimír. Změny metabolismu kostní tkáně u HIV pozitivních osob. Osteologický bulletin, 2013, 18(2), ISSN Páral J, Lochman P, Kalábová H, Hadzi-Nikolov GIST: current knowledge and treatment modalities. Rozhl Chir Apr;91(4): Paulusová, V., Laco, J., Dřízhal, I., Slezák, R.: Expression of matrix metalloproteinase 9 in oral lichen planus. Acta Medica (Hradec Králové), 2012 roč. 55, č. 1, s Pešek, M.,Kolek, V., Skřičková, J., Černovská, M., Koubková, L., Roubec, J., Salajka, F., Zemanová, M., Krejčí, J., Hejduk, K., Ryška, A., Minárik, M., Fiala, O. Common, uncommon, rare and complex EGFR mutations in Czech NSCLC patients and therapeutic effect of tyrosinkinase inhibitors Report Vol 2015;116(Suppl.): PIKA, T. - LOCHMAN, P. - KLINCOVÁ, M. - MAISNAR, Vladimír - TICHÝ, Miloš - ZAPLETALOVÁ, J. - SANDECKÁ, V. - ŠČUDLA, V. - HÁJEK, R.. Suprese alternativního páru 37 z 55

38 imunoglobulinu koreluje s mírou rizikovosti MGUS výrazněji nežli suprese hladin polyklonálních imunoglobulinů - dílč í výsledky vyšetření HevyLiteTM u MGUS. Klinická biochemie a metabolismus, 2012, 20(2), ISSN PIKA, Tomáš - LOCHMAN, P. - MAISNAR, Vladimír - TICHÝ, Miloš - MINAŘÍK, J. - HÁJEK, Roman - ŠČUDLA, Vladimír. Klinicko-laboratorní aspekty biklonální gamapatie nejistého významu - BGUS. Klinická biochemie a metabolismus, 2013, 21(2), ISSN PUDIL, Radek - PELOUCH, Radek - PRAUS, Rudolf - VAŠATOVÁ, Martina - HŮLEK, Petr. Heart Failure in patients with liver cirrhosis. Cor et Vasa, 2013, 55(4), E391-E396. ISSN PUDIL, Radek - PRAUS, Rudolf - HŮLEK, Petr - ŠAFKA, Václav - FEJFAR, Tomáš - VAŠATOVÁ, Martina - VOJÁČEK, Jan. Hemodynamické a echokardiografické změny u pacientů s jaterní cirhózou po provedeném transjugulárním intrahepatickém portosystémovém shuntu. Intervenční a akutní kardiologie, 2013, 12(1), ISSN X RADOCHA, Jakub - KLINCOVÁ, M. - MAISNAR, Vladimír - SANDECKÁ, V. - VÁVROVÁ, Jaroslava - ŠPIČKA, I. - ŠČUDLA, V. - GREGORA, E. - MACHÁLKOVÁ, Kateřina - TICHÝ, Miloš - MALÝ, Jaroslav - HÁJEK, R.. Význam stanovení FLC u nemocných MGUS a v kompletní remisi u mnohočetného myelomu. Klinická biochemie a metabolismus, 2012, 20(2), ISSN RADOCHA, Jakub - MAISNAR, Vladimír - KLINCOVÁ, Mária - VÁVROVÁ, Jaroslava - KAISAROVÁ, P. - HÁJEK, Roman - TICHÝ, Miloš - MALÝ, Jaroslav. Výsledky prvních analýz z registru RMG - význam volných lehkých řetězců v prognóze MGUS a hodnocení kompletní remise MM. Klinická biochemie a metabolismus, 2011, 19(2), ISSN ROSA, Jan - PAVLÍKOVÁ, Gabriela - PALIČKA, Vladimír. Osteonekróza čelisti u pacientů užívajících antiresorpční léčbu osteoporózy. Osteologický bulletin, 2013, 18(3), ISSN Ryška A.: Prediktivní makrery v léčbě solidních nádorů v praxi, Postgraduální medicína, 2014, 16, č. 3, s Ryška, A. Histologický registr mamárních karcinomů MAGISTER. Česko-slovenská patologie a Soudní lékařství, 2011, roč. 47, č. 2, s Ryška, A. Moderní diagnostika plicních nádorů úkol pro úzkou multidisciplinární spolupráci. Farmakoterapie, 2011, roč. 7, č. 2, s Ryška, A. Predictive biomarkers of immune response and immunotherapy. Prague Medical Report 2015;116(Suppl.): Ryška, A., Hovorková, E., Rozkoš, T., Laco, J.: Prediktivní diagnostika u karcinomu prsu. Česko-slovenská patologie a Soudní lékařství, 2011, roč. 56, č. 4, s Ryška, A., Petruželka, L., Skřičková, J., Kolek, V., Hajdúch, M., Matěj, R., Uvírová, M., Pešek, M., Dvořáčková, J., Hornychová, H.: Interdisciplinární konsenzus pro prediktivní vyšetřování u nemalobuněčného karcinomu plic (NSCLC) aktualizace Studia Pneumologica et Phthiseologica, 2012, roč. 72, č. 3, s Ryška, A., Zatloukal, P., Petruzelka, L., Skřičková, J., Kolek, V., Hajduch M., Matěj, R., Tichý, T., Benešová, L. Interdisciplinární konsensus pro prediktivní vyšetřování aktivačních mutací receptorů pro epidemoální růstový faktor (EGFR) u nemalobuněčného karcinomu plic. Farmakoterapie, 2011, roč. 7, č. 2, s Sedláková, I., Červinka, M., Tošner, J., Laco, J., Brigulová, K., Řezáč, A., Špaček, J., Škapinec, P. Drug resistence/sensitivity in vitro and clinical outcome in ovarian cancer 38 z 55

39 patients. Gynekolog, 2011, 20, 1, s Sedláková, I., Laco, J., Tošner, J., Caltová, K., Červinka, M., Řezáč, A., Špaček, J., Škapinec, P. Proteiny rezistence a chemorezistence u pacientek s karcinomem ovaria. Klin. Onkol., 2012, 25, 6, s Sedláková, I., Laco, J., Tošner, J., Špaček, J., Čermáková, E. Proteiny rezistence LRP, Pgp, MRP1, MRP3 a MRP5 u pacientek s karcinomem ovaria. Čes. Gynek., 2013, 78, 6, s Sedláková, I., Laco, J., Tošner, J., Špaček, J., Čermáková, E. Proteiny rezistence a PFS u pacientek s karcinomem ovaria. Gynekolog, 2013, 22, 4, s Sedláková, I., Laco, J., Tošner, J., Špaček, J.: Prognostický význam Pgp, MRP1 a MRP3 u pacientek s karcinomem ovaria. Ceska Gynekol 2015;80(6): Sedláková, L., Tošner, J., Červinka, M., Brigulová, K., Řezáč, A., Špaček, J., Laco, J., Škapinec, P.: Primární rezistence/senzitivita in vitro a klinický průběh onemocnění u pacientek s karcinomem ovaria. Čes. Gynekol., 2011, roč. 76, č. 3, s Sedláková, L., Tošner, J., Červinka, M., Brigulová, K., Řezáč, A., Špaček, J., Laco, J., Škapinec: Chemorezistence/chemosensivita in vitro u pacientek s karcinomem ovaria. Gynekologie, 2011, roč. 20, č. 2, s Sirák, I., Šinkorová, Z., Šenkeříková, M., Špaček, J., Laco, J., Vošmiková, H., John, S., Petera, J. Hypersensitivity to chemoradiation in FANCA carrier with cervical carcinoma - A case report and review of the literature. Rep Pract Oncol Radiother 2015;20(4): Slezák, R., Paulusová, V., Šembera, M., Laco, J.: Stručný přehled chorob parodontu vznikajících bez asociace s dentálním plakem. LKS (Suplement), 2013, 15, 9, s. K Sopirjaková, P., Podhola, M., Kopáčová, M., Tachecí, I., Hlista, M., Bártová, J., Rejchrt, S., Bureš, J.: Case : Small intestine difuse large B-cell lymphoma in a 58- year-old patient with coeliac disease. Acta medica (Hradec Králové), 2011, roč. 54, č. 1, s Soukup, T., Doseděl, M., Pávek, P., Nekvindová, J., Veleta, T., Kuběna, A., Tošovský, M., Vlček, J., Bradna, P. Polymorfismus C677T genu pro methylentetrahydrofolát reduktázu je spojen se změnou léčebné odpovědi na methotrexát v populaci revmatoidní artritidy Východočeského regionu. Česk Revmatol 2015;23(1): Svatoň,M., Pešek, M., Chudáček, Z., Vošmiková, H. Current Two EGFR Mutations in Lung Adenocarcinoma - Case Report. Klin Onkol 2015;28(2): ŠÁLEK, Tomáš - MORAVČÍKOVÁ, D. - HUMPOLÍČEK, P. - TICHÝ, Miloš - PALIČKA, Vladimír. The prevalence of decreased glomerular filtration rate in patients with monoclonal gammopathy of undetermined significance. Klinická biochemie a metabolismus, 2013, 21(1), ISSN Šponer, P., Urban, K., Kučera, T., Kohout, A., Brtková, J., Knížek, J.: The use of interconnected β-tricalcium phosphate as bone substitute after curettage of benign bone tumours. European Journal of Orthopaedic Surgery and Traumatology, 2011, Volume 21, Issue 4, pp Šťastný, K., Červinka, V., Šiller, J., Havlíček, K., Gatěk, J., Vachtová, M., Zedníková, I., Ňaršanská, A., Sovová, B., Třeška, V., Kubala, O., Prokop, J., Osatruszka, P., Dostalík, J., Hornychová, H., Hovorková, E., Ryška, A., Hácová, M., Rötreckel, P., Vážan, P., Velecký, J. Hes, O., Michal, M., Horáček, J., Buzrla, P., Čekan, M., Tomanová, R., Dvořáčková, J., 39 z 55

40 Záhora, J.: Prediktivní faktory postižení nonsentinelových uzlin u karcinomu prsu závěry české multicentrické studie sentinelových uzlin. Rozhledy v chirurgii, 2011, roč. 90, č. 6, s Štefánek, J., Morávková, P., Žák, P., Laco, J., Nová, M., Kopáčová, M.: Atypický obraz infiltrace tračníku lymfomem u pacienta s chronickou lymfatickou leukémií. Gastroent Hepatol 2015;69(2): Šteiner, I., Krbal, L., Laco, J., Rozkoš, T.: Kalcifikovaná aortální stenóza zánětlivé onemocnění. Onkologie, 2011, 5(Suppl. B), s. B Šteiner, I.: Česká eponyma v patologii. Česko-slovenská patologie a Soudní lékařství, 2013, roč. 49, č. 1, s Štěpán, J., Vaculík, J., Palička, V., Dungl, P. - Vyskočil, V., Pavelka, K. Péče o pacienty s nízkotraumatickou zlomeninou horního konce stehenní kosti. II. Následná osteologická péče. Doporučený postup České revmatologické společnosti, Společnosti pro metabolická onemocnění skeletu a České společnosti pro ortopedii a traumatologii. Česk Revmatol 2015;23(2): Štěpán, J., Vaculík, J., Palička, V., Dungl, P., Vyskočil, V., Pavelka, K. Péče o pacienty s nízkotraumatickou zlomeninou horního konce stehenní kosti. Následná osteologická péče. II., Doporučený postup České revmatologické společnosti, Společnosti pro metabolická onemocnění skeletu a České společnosti pro ortopedii a traumatologii. Osteologický bulletin 2015;20(2): Štichhauer, R., Koudelka, J., Rejtar, P., Kohout, A.: Retrogastrická bronchogenní cysta. Rozhledy v chirurgii, 2012, roč. 91, č. 3, s Švadlenková, R., Cyrany, J., Fejfar, T., Hoffmann, P., Matějková, A., Laco, J., Kopáčová, M. Neobvyklá příčina průjmu cholecystokolická píštěl: kazuistika a literární přehled. Gastroent Hepatol 2015;69(4): ŠVEJKOVSKÁ, Klára - GRADOŠOVÁ, Iveta - ŽIVNÁ, Helena - DOUBKOVÁ, Kristýna - ŽIVNÝ, Pavel - ČERMÁKOVÁ, Eva - PALIČKA, Vladimír. Vliv opakovaných odběrů krve a diety obohacené o železo na mechanické vlastnosti kostí potkanů. Osteologický bulletin, 2011, 16(4), ISSN Tachecí, I., Ryška, A. Virtual cases in internal medicine education. Mefanet J 2015;3(1): TICHÝ, Miloš - VÁVROVÁ, Jaroslava - MAISNAR, Vladimír. Zdvojené paraproteinémie - krátké sdělení. Klinická biochemie a metabolismus, 2011, 19 (40)(2), ISSN Tošovský, M., Bradna, P., Laco, J., Podhola, M., Soukup, T., Brožík, J.: Case : ANCA Associated Glomerulonephritis in Combination with IgG4-Positive Mediastinal Mass in a Patient with Ankylosing Spondylitis Treated with TNF Alpha Inhibitors. Acta Medica (Hradec Králové), 2012, roč. 55, č. 1, s Tuček, L., Doležalová, H., Laco, J., Leško, D.: Epulis congenita: Kazuistika. LKS, 2012, 22, 7-8, s Vaňásek, T., Repák, R., Laco, L., Volfová, M., Rejchrt, S.: Imunoglobulin G4 (IgG4) asociovaná cholangitida a pankreatitida - popis tří případů a přehled literatury. Gastroent. Hepatol, 2012, 66, S1, S25-S VÁVROVÁ, Jaroslava - FRIEDECKÝ, Bedřich. DEQAS - mezinárodní program hodnocení kvality stanovení vitaminu D. FONS, 2012, 2012(4), ISSN z 55

41 139. VELETA, Tomáš - SOUKUP, Tomáš - PÁVEK, Petr - NEKVINDOVÁ, Jana - VLČEK, Jiří - BRADNA, Petr. Farmakogenetika metotrexátu v léčbě revmatoidní artritidy. Klinická farmakologie a farmacie, 2013, 27(3-4), ISSN Vojáček Jan, Ivo Šteiner, Josef Špaček, Josef Bis, Jaroslav Dušek Analýza koronárního trombu u nemocných s infarktem myokardu: změna názoru na vznik akutního uzávěru věnčité tepny. Interv. Akut. Kardiol 2013; 12(4): Vošmik, M., Laco, J., Sirák, I., Leško, M., Repák, R., Dvořák, J., Melichar, B., Petera, J. Předoperační chemoradioterapie adenokarcinomů distálního jícnu, gastroezofageální junkce a žaludku výsledky léčby. Klin Onkol 2015;28(Suppl. 1):S Zavřelová, A., Matějková, A., Nová, M., Hoffmann, P., Buchta, V., Žák, P.: Case : Invasive Mucormycosis (Zygomycosis) after Bone Marrow Transplantation in a 26- Year-Old Man with Relapsing Acute Myeloid Leukaemia. Acta Medica, 2011; 54(4): ŽIVNÁ, Helena - MIČUDA, Stanislav - BRČÁKOVÁ-DOLEŽELOVÁ, Eva - ŽIVNÝ, Pavel. The effect of resveratrol on bone status in rats with bile duct obstruction. Open Journal of Endocrine and Metabolic Diseases, 2013, 3(1), ISSN ŽIVNÁ, Helena - ŽIVNÝ, Pavel - GRADOŠOVÁ, Iveta - ŠVEJKOVSKÁ, Klára - HUBENÁ, Soňa - ŽIVNÝ, Ondřej - PALIČKA, Vladimír. Akutní odraz operačního zásahu na metabolismus kostí u potkanů. Osteologický bulletin, 2011, 16(4), ISSN ŽIVNÝ, Pavel - PALIČKA, Vladimír - VYSKOČIL, Václav. Pagetova choroba. Postgraduální medicína, 2011, 13(7), ISSN ŽIVNÝ, Pavel - ŠVEJKOVSKÁ, Klára - GRADOŠOVÁ, Iveta - ŽIVNÁ, Helena - PALIČKA, Vladimír. Možnosti určení mechanické odolnosti kosti v experimentu - souhrn poznatků. Osteologický bulletin, 2011, 16(4), ISSN ŽIVNÝ, Pavel - ŽIVNÁ, Helena - GRADOŠOVÁ, Iveta - ŠVEJKOVSKÁ, Klára - HUBENÁ, Soňa - PALIČKA, Vladimír. Vliv dyslipidemických diet na kostní metabolismus u samců potkanů kmene Wistar. Osteologický bulletin, 2011, 16(4), ISSN c) Monography 1. BERÁNEK, Martin - TICHÝ, Miloš - CERMAN, Jaroslav - HOLEČKOVÁ, Magdalena - HYŠPLER, Radomír - KOCNA, Petr - MALÍŘOVÁ, Eva - ŠPIRKOVÁ, Jana - VÁVROVÁ, Jaroslava - ŽIVNÁ, Helena - ŽIVNÝ, Pavel. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Nakladatelství Karolinum - Univerzia Karlova v Praze, s. ISBN BORSKÁ, Lenka - FIALA, Zdeněk - ANDRÝS, Ctirad - KREJSEK, Jan - PALIČKA, Vladimír - HAMÁKOVÁ, Květoslava. Přínosy a rizika Goeckermanovy léčby psoriázy. 1. vyd. Brno: MDS, s. ISBN Čelakovský, P., Betka, J., Plzák, J. Astl, J., Berkovič, J., Chrobok, V., Klozar, J., Komínek, P., Laco, J., Mejzlík, J., Mrzena, L., Novosad, J., Stárek, I., Tedla, I., Vošmik, M., Dědková, J., Hodek, M., Kalfeřt, D., Krtičková, J., Matoušek, P., Ryška, A., Sirák, I., Šatanková, J., Žižka, J.: Krční metastázy, 1. vyd. Havlíčkův Brod: Tobiáš, 2012, s ISBN KRÁLÍKOVÁ, Eva - ALRADHI, Fuad Lotf - ANDERS, Martin - ASCHERMANN, Michael - BROULÍK, Petr - CÍFKOVÁ, Renata - CSÉMY, Ladislav - ČEŠKA, Richard - FELBR, Oldřich - FELBROVÁ, Vladislava - FEYREISL, Jaroslav - GREPLOVÁ, Jarmila - HAVRDOVÁ, Eva - 41 z 55

42 HERCOGOVÁ, Jana - HIRSCHFELDOVÁ, Kateřina - HRUBÁ, Drahoslava - HUBÁČEK, Jaroslav - JEDLIČKOVÁ, Anna - JENŠOVSKÝ, Jiří - JEŽEK, Martin - KINDL, Tomáš - KISLINGER, Radek - KMEŤOVÁ, Alexandra - KOBLÍŽEK, Vladimír - KOLEK, Vítězslav - KOSTELECKÁ, Lenka - KOZÁKOVÁ, Blanka - KRCH, František - KRTIL, Jan - KRUŽICOVÁ, Zuzana - KUBÁNEK, Jan - KUDELOVÁ, Jana - KULOVANÁ, Stanislava - KURCOVÁ, Ivana - LEŠTÁK, Ján - LINHART, Aleš - LUKÁŠ, Karel - MALÁ, Kateřina - MAREL, Miloslav - MAUROVICH HORVATH, Eszter - MICHALCOVÁ, Jana - MIKŠÍČKOVÁ, Jarmila - NECHANSKÁ, Blanka - NEUBAUEROVÁ, Barbora - NOVOTNÝ, Jaroslav - PAFKO, Pavel - PALIČKA, Vladimír - PETANOVÁ, Jitka - PERLÍK, František - POPOV, Petr - POSPÍŠIL, Libor - PRAUSOVÁ, Jana - ROSOLOVÁ, Hana - ROSS, Hana - ROUBÍČKOVÁ, Eva - SARNA, Linda - SADÍLEK, Petr - SKOUPÁ, Jana - SOCHOR, Ondřej - SOUKUP, Jan - SOVINOVÁ, Hana - STÁRKA, Luboslav - STUBBELFIELD, Kateřina - SUCHARDA, Petr - ŠIKOLOVÁ, Veronika - ŠONKA, Karel - ŠPIČÁK, Václav - ŠTAMPACH, Ivan - ŠTEFLOVÁ, Alena - ŠTĚPÁNKOVÁ, Lenka - TOUS, Yvona - TUČEK, Milan - VENCOVSKÝ, Jiří - VINAŘ, Oldřich - VRABLÍK, Michal - VRANOVÁ, Vilma - VRBA, Ivan - ZÁMEČNÍK, Libor - ZIMA, Tomáš - ZVOLSKÁ, Kamila - ZVOLSKÝ, Miroslav - ŽALOUDÍK, Jan - ŽALOUDÍKOVÁ, Iva. Závislost na tabáku - epidemiologie, prevence a léčba. 1. vyd. Břeclav: ADAMIRA, s. ISBN Laco, Jan: Lidské papilomaviry a jejich úloha v etiopatogenezi dlaždicobuněčného karcinomu dutiny ústní a orofaryngu. Galén, 2012, s 163. ISBN: MAISNAR, Vladimír - TICHÝ, Miloš - DULÍČEK, Petr - FRIEDECKÝ, Bedřich - GREGORA, Evžen - KREJSEK, Jan - MACHÁLKOVÁ, Kateřina - RADOCHA, Jakub - SMOLEJ, Lukáš - ŠOLCOVÁ, Lucie - VÁVROVÁ, Jaroslava. Monoklonální imunoglobuliny - výskyt, význam a možnosti jejich průkazu. 1. vyd. Hradec Králové: Nucleus HK, s. ISBN PALIČKA, Vladimír - BLAHOŠ, Jaroslav - BÝMA, Svatopluk. Osteoporóza: doporučený diagnostický a léčebný postup pro všeobecné praktické lékaře vyd. Praha: Společnost všeobecného lékařství ČLS JEP, s. ISBN Povýšil, C., Šteiner, I.: Obecná patologie, Galén, 2011, 290 s. 9. Rejchrt, S., Aabakken, L., Kopáčová, M., Douda, T., Tachecí, I., Cyrany, J., Kohoutová, D., Repák, R., Urban, O., Ryška, A., Podhola, M., Laco, J., Kohout, A., Hadži Nikolov, D.: Přenosy endoskopických výkonů. České gastroenterologické společnosti ČLS JEP. Endoskopická sekce. 2012, 1. vyd. Praha. ISBN Smilek, P., Plzák, J., Klozar, J. a kolektiv (Binková, H., Čelakovský, P., Černý, M., Dědková, J., Chrobok, V., Komínek, P., Laco, J., Mechl, Z., Mrzena, L., Novotný, T., Pellant, A., Petera, J., Rottenberg, J., Ryška, A., Slezák, R., Veselý, J., Veselý, M., Vošmik, M., Zábrodský, M.). Karcinomy dutiny ústní a hltanu. 1. Vydání. Havlíčkův Brod: Tobiáš, s. ISBN ŠIMKO, Julius - OŠLEJŠKOVÁ, Hana - HOVORKA, Jiří - PALIČKA, Vladimír. Osteopatie u epileptiků. 1. vyd. Olomouc: Solen, s. ISBN ZADÁK, Zdeněk - KVĚTINA, Jaroslav - ANDRÝS, Ctirad - BERÁNEK, Martin - BUKAČOVÁ, Olga - CIBIČEK, Norbert - ČEČKOVÁ, Eva - ČERVINKOVÁ, Zuzana - DRAHOTA, Zdeněk - HRONEK, Miloslav - HYŠPLER, Radomír - JANÁČKOVÁ, Soňa - KOCNA, Petr - KREJSEK, Jan - MARTÍNKOVÁ, Jiřina - PELIKÁNOVÁ, Terezie - ŠPELDA, Stanislav - TICHÁ, Alena - TRUBAČ, Roman - ŽĎÁNSKÝ, Petr - ŽIVNÝ, Pavel. Metodologie předklinického a klinického výzkumu. 1. vyd. Praha: Galén, s. ISBN d) Chapter in a book 1. BERÁNEK, Martin. Historie klinické biochemie. Vybrané kapitoly z klinické biochemie pro 42 z 55

43 studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Vyšetření v klinicko-biochemické laboratoři. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Automatizace v klinické biochemii. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Vlastnosti laboratorních metod. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Kontrola kvality v klinické biochemii. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Dokumentace v klinické laboratoři. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Úloha klinické biochemie v diagnostice diabetu mellitu. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Vyšetření parametrů lipidového metabolismu. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Jaterní poruchy a jejich laboratorní diagnostika. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Látky nebílkovinného charakteru obsahující dusík. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Úloha bioanalytika v klinicko-biochemické laboratoři. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin - ŽIVNÝ, Pavel. Rozmezí referenčních hodnot vybraných analytů. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Metody molekulární biologie. Obecná a klinická biochemie. 2. vyd. Praha: Karolinum, s ISBN BERÁNEK, Martin. Molekularní biologie v biomedicínském výzkumu. Metodologie předklinického a klinického výzkumu v metabolismu, výživě imunologii a farmakologii. 1. vyd. Praha: Galén, s ISBN CIBIČEK, Norbert - ŽIVNÝ, Pavel. Mikrodialýza a její využití v experimentálním a klinickém výzkumu. Metodologie předklinického a klinického výzkumu v metabolismu, výživě, imunologii a farmakologii. 1. vyd. Praha: Galén, s ISBN Dvořák, J., Sitorová, V., Ryška, A., Sirák, I., Richter, I., Hatlová, J., Melichar, B., Petera, J.: 43 z 55

44 Vliv předoperační radiochemoterapie na expresi EGFR adenokarcinomu rekta. Radiační onkologie, 2012, 1. vyd., Hradec Králové: Klinika onkologie a radiologie LFUK a FN Hradec Králové, s ISBN HYŠPLER, Radomír - KOCNA, Petr. Klinicko-biochemická vyšetření v gastroenterologii. Vybrané kapitoly z klinické biochemie. 1. vyd. Praha: Karolinum, s ISBN PALIČKA, Vladimír. Antikonvulzíva a metabolismus kostní tkáně. Osteopatie u epileptiků. 1. vyd. Olomouc: Solen, s ISBN Šteiner, I.: Poruchy krevního oběhu. Obecná patologie, Galén, 2011, s ŽIVNÝ, Pavel - HYŠPLER, Radomír. Metabolismus a analýza iontů. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN ŽIVNÝ, Pavel. Interpretace výsledků klinicko-biochemických vyšetření. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN ŽIVNÝ, Pavel. Klinická enzymologie. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika. 1. vyd. Praha: Karolinum, s ISBN II. Major scientific results: We consider the following results as significant because they announce a new discovery or lead to an earlier application in clinical practice. 1. Bouchal, P., Dvořáková, M., Roumeliotis, T., Bortlíček, Z., Ihnatová, I., Procházková, I., Ho, J.T.C., Maryáš, J., Imrichová, H., Budinská, E., Vyzula, R., Garbis, S.D., Vojtěšek, B., Nenutil, R. Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κb (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer. Mol Cell Proteomics 2015;14(7): (IF2014: 6,564) 2. Faltejskova, P., Svoboda, M., Srutova, K., Mlcochova, J., Besse, A., Nekvindova, J., Radova, L., Fabian, P., Slaba, K., Kiss, I., Vyzula, R., Slaby, O. Identification and functional screening of micrornas highly deregulated in colorectal cancer. J Cell Mol Med 2012;16(11): (IF2011: 4,125) 3. Reichl, P., Fang, M., Starlinger, P., Staufer, K., Nenutil, R., Muller, P., Greplova, K., Valik, D., Dooley, S., Brostjan, C., Gruenberger, T., Shen, J., Man, K., Trauner, M., Yu, J., Gao, C.F., Mikulits, W. Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma. Int J Cancer 2015;137(2): (IF2014: 5,085) 4. CIZKOVA, M., A. SUSINI, S. VACHER, G. CIZERON-CLAIRAC, C. ANDRIEU, K. DRIOUCH, E. FOURME, R. LIDEREAU a I. BIÉCHE. PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups. Breast Cancer Research. 2012, 14(1), Article Number: R28. ISSN X. IF (2011): CIZKOVA, M., M.E. DUJARIC, J. LEHMANN-CHE, V. SCOTT, O. TEMBO, B. ASSELAIN, J.Y. PIERGA, M. MARTY, CREMOUX, P. DE, F. SPYRATOS a I. BIÉCHE. Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab. British Journal of Cancer. 2013, 108(9), ISSN IF (2012): Croce, S., Ribeiro, A., Brulard, C., Noel, J.C., Amant, F., Stoeckle, E., Devouassoux- Shisheborah, M., Floquet, A., Arnould, L., Guyon, F., Mishellany, F., Garbay, D., Cuppens, T., Zikan, M., Leroux, A., Frouin, E., Duvillard, P., Terrier, P., Farre, I., Valo, I., MacGrogan, 44 z 55

45 G.M., Chibon, F. Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. Mod Pathol 2015;28(7): (IF 6.187) 7. GEORGAPOULOU, E. A., K. TSIMARATOU, K. EVANGELOU, P. J. FERNANDEZ-MARCOS, V. ZOUMPOURLIS, I. P. TROUGAKOS, D. KLETSAS, J. BARTEK, M. SERRANO a V.G. GORGOULIS. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. AGING-US.2013, 5(1), ISSN IF (2012): GUERRERO-PRESTON, R., C. MICHAILIDI, L. MARCHIONNI, C.R. PICKERING, M.J. FREDERICK, J.N. MYERS, S. YEGNASUBRAMANIAN, T. HADAR, M.G. NOORDHUIS, V. ZIZKOVA, E. FERTIG, N. AGRAWAL, W. WESTRA, W. KOCH, J. CALIFANO, V.E. VELCULESCU a D. SIDRANSKY. Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer. Epigenetics. 2014, 9(7), ISSN IF (2013): JANECKOVA, H., K. HRON, P. WOJTOWICZ, E. HLIDKOVA, A. BARESOVA, D. FRIEDECKY, L. ZIDKOVA, P. HORNIK, D. BEHULOVA, D. PROCHAZKOVA, H. VINOHRADSKA, K. PESKOVA, P. BRUHEIM, V. SMOLKA, S. STASTNA a T. ADAM. Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders. Journal of Chromatography A. 2012, 1226(-), ISSN IF (2011): KRIEGOVA, E., R. FILLEROVA, T. TOMANKOVA, B. HUTYROVA, F. MRAZEK, T. TICHY, V. KOLEK, BOIS, R.M. DU a M. PETREK. T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis. European Respiratory Journal. 2011, 38(5), ISSN IF (2010): KUBICZKOVA, L., F. KRYUKOV, O. SLABY, E. DEMENTYEVA, J. JARKOVSKY, J. NEKVINDOVA, L. RADOVA, H. GRESLIKOVA, P. KUGLIK, E. VETESNIKOVA, L. POUR, Z. ADAM, S. SEVCIKOVA a R. HAJEK. Circulating serum micrornas as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance.haematologica. 2014, 99(3), ISSN IF (2013): MOJZIKOVA, R., P. KORALKOVA, D. HOLUB, Z. ZIDOVA, D. POSPISILOVA, J. CERMAK, Z.S. LALUHOVA, K. INDRÁK, M. SUKOVA, M. PARTSCHOVA, J. KUCEROVA, M. HORVATHOVA a V. DIVOKY. Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in the PKLR gene (p.arg518fs), and low hepcidin to ferritin ratios. British Journal of Haematology. 2014, 165(4), ISSN IF (2013): MRAZEK, F., A. STAHELOVA, E. KRIEGOVA, R. FILLEROVA, M. ZURKOVA, V. KOLEK a M. PETREK. Functional variant ANXA11 R230C: true marker of protection and candidate disease modifier in sarcoidosis. Genes and Immunity. 2011, 12(6), ISSN IF (2010): OPLUSTILOVA, L., K. WOLANIN, M. MISTRIK, G. KORINKOVA, D. SIMKOVA, J. BOUCHAL, R. LENOBEL, J. BARTKOVA, A. LAU, MJ. O CONNOR, J. LUKAS a J. BARTEK. Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. Cell Cycle. 2012, 11(20), ISSN IF (2011): PEURALA, H., D. GRECO, T. HEIKKINEN, S. KAUR, J. BARTKOVA, M. JAMSHIDI, K. AITTOMAKI, P. HEIKKILA, J. BARTEK, C. BLOMQVIST, R. BUTZOV a H. NEVANLINNA. MiR- 34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer. Plos One. 2011, 6(11), e ISSN IF(2010): z 55

46 16. Skalová, A., Altemani, A., Silvana Di Palma, Roderick HW Simpson, Hosticka, L., Andrle, P., Laco, L., Toner, M., Vozmitsel, MA., Szakacs, S., Kazakov, DV.,Kinkor, Z., Michal, M.: Pleomorphic Adenoma of the Salivary Glands With Intravascular Tumor Deposits A Diagnostic Pitfall. American Journal of Surgical Pathology, 2012, roč. 36, č. 11, s IF= STRAUSS, R., Z.Y. LI, Y. LIU, I. BEYER, J. PERSSON, P. SOVA, T. MÖLLER, S. PESONEN, A. HEMMINKI, P. HAMERLIK, C. DRESCHER, N. URBAN, J. BARTEK a A. LIEBER. Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity. Plos One. 2011, 6(1), e ISSN IF (2010): SURINOVA, S., M. CHOI, S. TAO, P.J. SCHÜFFLER, C.Y.. CHANG, T. CLOUGH, K. VYSLOUŽIL, M. KHOYLOU, J. SROVNAL, Y. LIU, M. MATONDO, R. HÜTTENHAIN, H. WEISSER, J.M. BUHMANN, M. HAJDÚCH, H. BRENNER, O. VITEK a R. AEBERSOLD. Prediction of colorectal cancer diagnosis based on circulating plasma proteins. EMBO Molecular Medicine. 2015, 7(9), ISSN IF (2014): SURINOVA, S., L. RADOVÁ, M. CHOI, J. SROVNAL, H. BRENNER, O. VITEK, M. HAJDÚCH a R. AEBERSOLD. Non-invasive prognostic protein biomarker signatures associated with colorectal cancer. EMBO Molecular Medicine. 2015,7(9), ISSN IF (2014): Tambor, V., Kacerovský, M., Andrýs, C., Musilová, I., Hornychová, H., Plíšková, L., Link, M., Stulík, J., Lenčo, J.: Amniotic Fluid Cathelicidin in PPROM Pregnancies: From Proteomic Discovery to Assessing Its Potential in Inflammatory Complications Diagnosis. PLoS ONE, 2012, roč. 7, č. 7, nestránkována. IF=4.092 D. Utilization of the LI Describe the strategy for the allocation of capacity of the LI. Indicate the utilisation of the LI s capacity (according to the type and scientific field of the LI, describe the percentage utilisation, eventually number of accesses, volume of produced, stored or provided data, including the percentage distribution of users by their affiliation universities, public research institutions, industry) for the entire period. In case of construction of the LI describe the status of the LI at the end of this period or data from performed tests or limited service providing, etc. In the Czech Republic, cancer is one of the major threats to the overall health. For some diagnoses, such as colorectal carcinoma, the Czech Republic occupies one of the top positions for incidence worldwide. In order to provide the national scientific community with the patientderived biological material to perform research the general idea to establish BBMRI_CZ was to reflect the imminent need of the Czech population and healthcare system to focus research on the diseases that represent major threat to our citizens. Furthermore, as the research and cost of new target-oriented cancer therapeutics continues to rise, there is an imperative need to improve the research => clinical application transition and to enable only high-quality research results to be further explored as potential diagnostic and therapeutic targets. In the light of numerous recent publications on poor research reproducibility ( the BBMRI community realizes that the overall quality of the source material for all the areas of biomedical research represents in fact a critical parameter of research outputs. The primary vision and the main output of biobanking processes at the same time is patient oriented added value, i.e. a) a newly acquired knowledge on disease epidemiology and ethiopathogenesis, b) a new diagnostic procedure, c) a new or innovated therapeutic procedure, or d) an innovated theranostic procedure, i.e. a procedure combining diagnostic and therapeutics 46 z 55

47 capabilities. All these outputs represent key requirements of so called personalized/precision medicine ; ( wp1617-health_en.pdf). E. Cooperation I. Indicate newly established and running cooperation within the Czech Republic and abroad with research institutions, industry and other entities using results of the LI. II. Indicate newly established and running cooperation with other research infrastructures in the field, both Czech and foreign ones, for the entire financial period. An important international position of the Czech infrastructure was achieved by the establishment of BBMRI_ERIC consortium where the position of the Czech republic is statutorily embeded within the BBMRI-ERIC founding document (2013/701/EU). BBMRI_CZ, the Czech part of the infrastructure is thus actively participating in the management of the consortium through its Assembly of Members (the Czech MEYS representative is Mgr. Petr Ventulka/the National coordinator is assoc. professor Dalibor Valík) and in its executive activities through its National node. These include particularly conceptual activities, strategies of research development, operational activities of BBMRI-ERIC Management Committee and expert groups (Common Services such as CS IT and CS ELSI). The Czech part of infrastructure exerts the direct effect on research and operational heading of BBMRI-ERIC consortium by this way. The following diagram describes BBRMI-ERIC full members and observers. 47 z 55

48 Fig. 3. BBMRI-ERIC full members and observers. BBMRI-ERIC full members (in dark blue) include Kingdom of Belgium, Czech Republic, Federal Republic of Germany, United Kingdom of Great Britain and Northern Ireland, Republic of Estonia, Hellenic Republic, French Republic, Italian Republic, Republic of Malta, Kingdom of Netherlands, Republic of Austria, Republic of Finland, Kingdom of Sweden. The observers (in light blue) are Kingdom of Norway, Republic of Poland, Switzerland, and Turkey. The National Node and partner institutions participate besides BBMRI_CZ activities also in a number of international cooperation aimed at the development of biological and medical research, as it is indicated in progress reports. BBMRI-ERIC, of which we are a part, is a European legal subject with the purpose to coordinate European biobanks activities and to strenghten the link between basic and translational research in medical and biological science. The participation of the Czech Republic complies with BBMRI- ERIC portfolio and activities. The portfolio of services, approaches and research activities is embeded in relevant BBMRI-ERIC documents. The primary aim of BBMRI_CZ within BBMRI-ERIC is to adhere to the European biobanking policy and to implement it as it is set by the statutory body (AoM, Assembly of Members) and governing body (Management Committee) and particular documents, i.e. Statutes, Work Programme and others. The direct interantional cooperation is realized through: Active participation in international conferences and congreses within BBMRI-ERIC and outside, through active participation in the creation of BBMRI members obligatory document Work Programme 2016, active work within particular workpackages of the overall work plan BBMRI_CZ is active in clinical biobanks or access packet. Common Services - the Czech infrastructure is active especially in the CS IT group focused on IT issues of biobanking, data flow and clinical data integration all these under ensuring of necessary data security, integrity and adherence with ethic regulatory standards. The novel data tool is beeing discussed between consortium members for its possible utilization in broadening the data tool set for searching of clinical samples sets intended for particular research projects. Other BBMRI_CZ activites are within CS ELSI. Active participation in the preparation of the projects H2020, such as ADOPT BBMRI_ERIC and EGI project. Active participation in new normatives for biobank operation, active participation in the development of standards ISO/TC standards concerning the proper handling with samples, its processing and storage and the the quality control system in biobank, and the transfer of the standards into practice (preanalytical phase sampling on a clinic). The realization of long-term cooperation between participating institutions in the field of specific expertise such as tumor biology, clinical cancer research, biomarker research, immunooncology, epidemiologic aspects of cancer, rare diseases clinicaly projecting into oncology. 48 z 55

49 F. Users For the entire period indicate the number of users (eventually number of accesses) of the LI from the Czech Republic and abroad. Indicate the number of conferences and seminars organized by the LI, including the number of participants from the Czech Republic and abroad. Indicate the number of meetings with users and the feedback results thus obtained. Indicate the number of agreements with other institutions (e.g. contracts, memoranda). The infrastructure does not generate results without participation of infrastructure staff. This emanates from infrastructure policy where the provision of material includes also the expertise (biological material processing, data processing, experiment realization or participation) leading to the co-authorship of publication or product. BBMRI_CZ research infrastructure ensures high quality biological material for needs of czech medical research community that is used for research projects ongoing in partner institutions. It is necessary to keep the resources available for academic and medical research institutions due to their competitivness at national and international field (grant agencies, Horizon2020, etc.; of academic subject are pressumed based on the evaluation of research institutions, mainly from the contribution to the Index of scientific results (RIV) (scientific articles, patents, etc.)). The primary users of the infrastructure are authorized and verified subjects that directly participate in research using all the resources of biological material and expertises. The group is potentially large and the aim of the infrastructure is to extend and increase the productivity of the research and to facilitate the aplication of the research results into the clinical practice (examples: clinical and experimental departments of MMCI, partner institutions, some departments of AS, other universities, new centers of excelence such as CEITEC, etc.). This category will include also the cooperation between academia/industry, yet infrequent. The secondary users are those who use the product of primary users and produce an added value on its basis (i.e. they use standard operation procedures -SOPs, standards and directives or proceed from research outputs such as publications, books, recommendations, like e.g. the Blue book of The Czech Oncological Society, or Recommendations on the utilization of tumor markers in clinical practice, in their further research or publication activity). This group of users is unlimited and its extent may be estimated from the number of citations, recommendations and other writen and public documents created in relation and cooperation with biobanks (examples: a clinican, scientific community in medical sciences, in certain biological sciences such as tumor biology, interdisciplinary medical cooperation, etc.). G. Internationalization For the entire period indicate the number of international research grants connected to the LI gained by research team, their names, a brief description and financial volume. NN BBMRI_CZ is so called third party BBMRI-ERIC within the projects such as H2020 ADOPT BBMRI_ERIC and EGI_ENGAGE. The project is within the BBMRI Competence Center (a part of WP6) focused on distributed/paralel biobanking data processing using private and federated cloud technologies while the subject of the research are data sensitive for privacy of the donors (privacy-sensitive data both raw, pseudonymized or at certain level of anonymization). Our IT specialist Mgr. Ondřej Vojtíšek is working on this project and externaly we cooperate with assoc. professor Petr Holub who is currently the head of BBMRI-ERIC IT section. 49 z 55

50 H. Multidisciplinarity Indicate the number and titles of scientific disciplines that use the LI s services. Append concrete results. The BBMRI_CZ infrastructure uses human biological material and thus the cooperation is limited to medical and biological disciplines, where the biologic material handling is regulated by national and European legislation. Here we can state especially oncology and oncological research, cell and tumor biology, immunology, pharmacology, biochemistry and clinical biochemistry. IT services CERIT SC, the overall BBMRI activity is inconceivable without its cooperation with IT Services (IT infrastructure for medicine, i.e. research and development of IT infrastructure for medical applications, assoc. professor P. Holub, the director of BBMRI-ERIC IT Services). The international activities are linked through EGI-ENGAGE, the cooperation and modeling for privacysnsitive data, and the cooperation with the Institute of Biostatistics and Analyses (IBA) in the field of biostatistics, epidemiology and bioinformatics, assoc. professor Dušek, head of ÚZIS. I. Strategic Management of the Scientific Development of the LI Indicate the main features of the scientific strategy of the LI used in the past financial period, including plan for update of used technology and plan of possible decommissioning. Indicate experience with this scientific strategy and possible changes proposals for the future. The strategy of research development is controled by the governing institution of the infrastructure for the whole period of implementation. The overall organizational concept and BBMRI_CZ system implementation was described and published in The biobanking research infrastructure BBMRI_CZ: a critical tool to enhance translational cancer research. Holub P, Greplova K, Knoflickova D, Nenutil R, Valik D. Klin Onkol. 2012;25 Suppl 2:2S78-81 (full text available on the Web). The overall RI is realized through the organizational structures of partner institutions as described. The initial international presentation of BBRMI_CZ conception was carried out at BBMRI-ERIC kick-off meeting in Graz A. The management of processes and activities within BBMRI_CZ system The source laboratories for BBMRI_CZ project (i.e. the labs where a part of patient biological material for biobanking storage is sampled, see Fig. 4) are currently acredited either by CIA according to the ISO standard at MMCI (The Dept. of Oncological Pathology - subject No. 8086, certificate No. 362/2014; Dept. Of Laboratory Medicine subject No. 8084, certificate No. 347/2014), at FM1 CU Prague (Institute of Pathology subject No. 8163, certificate No. 199/2014, Institute of Medical Biochemistry and Laboratory Diagnostic subject No. 8041, certificate No. 312/2014), FM CU Hradec Králové (Fingerland Department of Pathology subject No. 8091, certificate No. 292/2013), FM PU Olomouc (Institute of Molecular and Translational Medicine, subject No. 8243, certificate No. 135/2013) or accredited by NASKL according to the ISO standard at MMCI (The Dept. of Oncological Pathology), FM1 CU Prague (Institute of Pathology), MF CU Hradec Králové (Fingerland Department of Pathology, Institute of Clinical Biochemitry and Diagnostics), FM PU Olomouc (Department of Clinical and Molecular Pathology), MF CU Plzeň (Institute of Clinical Biochemistry and Haematology, Department of Nuclear Medicine Bory Laboratory of Immunochemical Diagnostics). Following diagram (Fig. 4) describes links between the activities of medical faculties and tertiary university hospitals or their specialized institutes in the area of human biobanking within BBMRI_CZ model. 50 z 55

51 Fig. 4. The interconnection of the activities of medical faculties and tertiary university hospitals or their specialized institutes in the area ofa human biobanking specialized institute within BBMRI_CZ model. B. The strategic cooperation and long-term activities planning The following chart (Fig. 5) demonstrates a life cycle of patient biological sample aliquot intended for research purposes and interaction with other research infrastructures in medical sciences (The biospecimen life cycle; the respective activities at the EATRIS level pertain to users-research community/applications and CZECRIN activities to research community/applications-patient ). Fig. 5. The life cycle of biospecimen aliquot. C. IT management related to infrastructure activities with the continuity to the university hospitals The IT development encompassed a gradual integration of information from particular biobanks. The process included the development of first infrastructure versions in In it was followed by upgrading of search engines for how to apply for biospecimen and involving the mechanism for keeping the autonomy in sample administration and keeping the compatibility with the informed consent. Finally, the integration with other biobanking systems in was carried out. 51 z 55