Transanální operace Wolfovým rektoskopem

Transkript

1 33. ČESKÝ A SLOVENSKÝ GASTROENTEROLOGICKÝ KONGRES PRAHA 2015 Transanální operace Wolfovým rektoskopem Hladík P. Skořepa J., Polanecký O., Pastor J. Adámek S. III. chirurgicka klinika 1. LF UK Praha, FN Motol

2 TEMS Transanal Endoscopic MicroSurgery

3 Endoskopická Miniinvazivní Mikrochirurgická Transanální Stereooptická - 3D TEMS

4 TEMS Gerhar Buess Gerhard Buess Tübingen Tübingen Buess G, Hutterer F, Theiss J, Bobel M, Is Buess G, Hutterer F, Theiss J, Bobel M, Isselhard W, Pichlmaier H. [A system for a transanal endoscopic rectum operation]. Chirurg. 1984;55: ansanal endoscopic rectum operation]. Chirurg. 1984;55:677-80

5 TEMS - instrumentarium

6 Technika vyžaduje speciální edukaci operatéra Harmonický skalpel Snižení krvácení Přehlednost Zkrácení operace

7 TEMS poloha pacienta

8 TEMS - anatomické možnosti Přední stěna 12cm Laterální stěna 15cm Zadní stěna 20cm Resekce na volném střevě Cirkulární léze

9 TEMS - indikace Benigní polypy adenomy karcinoidy stenozy vysoká píštěl endometrioza abscesy prolapsy cévní dysplazie Maligní adenokarcinom kurabilní Tis, T1N0M0 G1-2 L0 Podmíněně kurabilní T2N0M0 G1-2 L0 Paliativní high-risk Ca T1, T2 T3, T4

10 TEMS diagnostika Per rectum!!! Kolonoskopie Rektoskopie Biopsie histologie EndoUZ MRI? CT plic CT břicha Onkomarkery PET/CT při susp. na meta postižení?

11 TEMS - resekce submukozní resekce parciální resekce resekce celé stěny

12 Zóny reskce Zona parciální reskce Zona transmurální resekce

13 TEMS technika resekce

14 TEMS technika sutury

15 Preparát

16 TEMS - adenomy TEM x TAE x ESD x EMR Early local recurrence after single intervention in the EMR series was significantly higher than in the TEM series (11.2 vs 5.4%, respectively;p=0.04) Barendse RM, van den Broek FJC, Dekker E et al. Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas. Endoscopy 2011;43: They reported a significantly higher local recurrence rate after TE than after TEM (31.5 vs 8.8%, respectively). Langer C, Liersch T, Su ss M et al. Surgical cure for early rectal carcinoma and large adenoma: transanal endoscopic microsurgery (using ultrasound or electrosurgery) compared with conventional local and radical resection. Int J Colorectal Dis 2003;18:

17 TEMS - adenomy TEM x TE x ESD x EMR ESD is an effective procedure for treating noninvasive non-polypoid colorectal tumors. These tumors may be difficult to resect en bloc by conventional EMR. The use of ESD results in a higher en-bloc resection rate and is less invasive than surgery. Colorectal endoscopic submucosal dissection: Technical advantages compared to endoscopic mucosal resection and minimally invasive surgery Yutaka Saito,1 Masayoshi Yamada,1 Eriko So,1 Seiichiro Abe,1 Taku Sakamoto,1 Takeshi Nakajima,1 Yosuke Otake,1 Akiko Ono2 and Takahisa Matsuda1 1Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan; and 2Digestive Diseases Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain The ESD procedure appears to be a safe technique, but TEM achieves a higher R0 resection rate when performed in full-thickness fashion, significantly reducing the need for further abdominal treatment. The R0 resection rate was 74.6 % (95 % CI %) for the ESD patients versus 88.5 % (95 % CI %) for the TEM patients (P\0.001). Systematic review and meta-analysis of endoscopic submucosal dissection versus transanal endoscopic microsurgery for largenoninvasive rectal lesions Alberto Arezzo Received: Surg Endosc (2014) 28:

18 TEMS - karcinom rekta indikace Tis, T1N0M0, G1-2, L0, V0, PNI 0 Velikost 3cm Okraje min.3mm Vzdálenost max. 8-12cm Max % obvodu Mobilita léze St.p. EPE malignizovaného polypu - nejasná histologie

19 Multidisciplinary team MDT Chirurg Onkolog Radiolog Gastroenterolog Patolog

20 Guidelines Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up These Clinical Practice Guidelines are endorsed by the Japanese Society of Medical Oncology (JSMO) Correspondence to: ESMO Guidelines Working Group, ESMO Head Office, Via L. Taddei 4, CH-6962 Viganello-Lugano, Switzerland;

21 nemožnost současné lymfadenektomie studie zabývající se rizikem vzniku uzlinových a vzdálených metastáz

22 Invaze do submukózy (pt1, Vienna 5) stopkaté polypy - Haggitt přisedlé léze (sessile) - Kikuchi

23 Haggitt level 1,2,3 = Kikuchi Sm1 level 4 = Sm1, Sm2 or Sm3

24 Kikuchi Levels and LN involvement T1 sm1a Invasive depth <1/3 through submucosa, usually <0.3mm. Invades <1/3 of width of adenoma T1 sm1b Invasive depth <1/3 through submucosa, usually <0.3mm. Invades >1/3 & <2/3 of width of adenoma T1 sm1c Invasive depth <1/3 through submucosa, usually <0.3mm. Invades >2/3 of width of adenoma T1 sm2 Invasive depth >1/3 and <2/3 of submucosa T1 sm3 Invasive depth >2/3 of submucosa but not into M.propria 1-3% 8-10% 23-25% Kikuchi et al Dis Colon Rectum 1995; 38: 1286

25 Management malignizovaných sm1 polypů kurativní výkon, když nejsou další rizikové faktory sm2 stopkatý kurativní, pokud je čistý resekční okraj sm2 přisedlý doporučuje se chirurgická resekce sm3 chirurgická resekce nutná

26 TEM vs. TME For patients with T1 rectal cancer, the distant metastasis, overall survival and disease-free survival rates did not differ between the TEM and TME groups, although the local recurrence rate after TEM was higher than that after TME Comparison of Transanal Endoscopic Microsurgery and Total Mesorectal Excision in the Treatment of T1 Rectal Cancer: A Meta-AnalysisJun-Yang Lu, Guo-Le Lin*, Hui-Zhong Qiu, Yi Xiao, Bin Wu, Jiao-Lin Zhou Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China , PLOS ONE DOI: /journal.pone October 27, 2015 Globally, a significantly lower postoperative complication rate was reported after TEM, compared with TME (8.2 vs 47.2%; P=0.01), with no mortality, confirming the safety of TEM, even in the treatment of early rectal cancers. A significantly higher local recurrence rate was found after TEM (12 vs 0.5%; P=0.004). However, the wide range of local recurrence rates from 4 18% Wu Y, Wu YY, Zhu BS et al. TEM and conventional rectal surgery for T1 rectal cancer: a meta-analysis. Hepatogastroenterology 2011;58:

27 TEM x TME Ten trials including 942 patients were retrieved. There was a trend toward a higher risk of local recurrence (odds ratio 2.78; 95% confidence interval 1.42, 5.44; z = 2.97; P < 0.003) and overall recurrence (P < 0.01) following TEMS compared with RR. The risk of distant recurrence, overall survival (odds ratio 0.90; 95% confidence interval 0.49, 1.66; z = 0.33; P = 0.74) and mortality was similar. TEMS was associated with a shorter operation time and hospital stay and a reduced risk of postoperative complications (P < ). The included studies, however, were significantly diverse in stage and grade of rectal cancer and the use of neoadjuvant chemoradiotherapy. M. S. Sajid, S. Farag, P. Leung, P. Sains, W. F. A. Miles and M. K. Baig Department of General and Laparoscopic Colorectal Surgery, Western Sussex Hospitals NHS Trust, Worthing Hospital, Worthing, UKSystematic review and meta-analysis of published trials comparing the effectiveness of transanal endoscopic microsurgery and radical resection in the management of early rectal cancer.colorectal Dis Jan;16(1):2-14. doi: /codi.12474

28 Vlastní soubor -TEM

29 Výsledky FN Motol výkonů s 3 konversemi do laparotomií. Z 92 výkonů TEM bylo histologicky potvrzeno 38 karcinomů - 41% 22 pacientů odesláno s dg. karcinomu U 40 pacientů, kteří byli odesláni s dg. nezhoubného polypu, byl karcinom nalezen v 16 případech, tedy v 40%.

30 Pooperační komplikace n=4 4,2% 3 x močová retence 1 x krvácení

31 Časné recidivy do 1 roku 5/36 13,8 %

32 Závěr TEM je ověřená a bezpečná metoda Prioritní postavení v resekcích objemných adenomů Kurativní léčba low risk časného karcinomu rekta Paliativní léčba u vyšších stadií karcinomu rekta Zlatý standard léčby karcinomu rekta je stále chirurgická resekce + TME

33 Závěr Pečlivý předoperační staging Histopatologie Vídeňská klasifikace, hodnocení invaze do submukozy, velikost, lokalizace, grading, lymfatická invaze, venozní invaze, buding Individuální přístup

34 Děkuji za pozornost Koloproktologická skupina III. chirurgické kliniky 1. LF UK a FN Motol Prof. MUDr. Svatopluk Adámek, CSc. MUDr. Pavel Hladík MUDr. Jiří Skořepa MUDr. Ondřej Polanecký MUDr. Jan Pastor